PMID- 9587072
OWN - NLM
STAT- MEDLINE
DCOM- 19980528
LR  - 20190909
IS  - 0955-3002 (Print)
IS  - 0955-3002 (Linking)
VI  - 73
IP  - 4
DP  - 1998 Apr
TI  - Track structure in radiation biology: theory and applications.
PG  - 355-64
AB  - PURPOSE: A brief review is presented of the basic concepts in track structure and 
      the relative merit of various theoretical approaches adopted in Monte-Carlo 
      track-structure codes are examined. In the second part of the paper, a formal 
      cluster analysis is introduced to calculate cluster-distance distributions. 
      METHOD: Total experimental ionization cross-sections were least-square fitted and 
      compared with the calculation by various theoretical methods. Monte-Carlo 
      track-structure code Kurbuc was used to examine and compare the spectrum of the 
      secondary electrons generated by using functions given by Born-Bethe, Jain-Khare, 
      Gryzinsky, Kim-Rudd, Mott and Vriens' theories. The cluster analysis in track 
      structure was carried out using the k-means method and Hartigan algorithm. 
      RESULTS: Data are presented on experimental and calculated total ionization 
      cross-sections: inverse mean free path (IMFP) as a function of electron energy 
      used in Monte-Carlo track-structure codes; the spectrum of secondary electrons 
      generated by different functions for 500 eV primary electrons; cluster analysis 
      for 4 MeV and 20 MeV alpha-particles in terms of the frequency of total cluster 
      energy to the root-mean-square (rms) radius of the cluster and differential 
      distance distributions for a pair of clusters; and finally relative frequency 
      distribution for energy deposited in DNA, single-strand break and double-strand 
      breaks for 10MeV/u protons, alpha-particles and carbon ions. CONCLUSIONS: There 
      are a number of Monte-Carlo track-structure codes that have been developed 
      independently and the bench-marking presented in this paper allows a better 
      choice of the theoretical method adopted in a track-structure code to be made. A 
      systematic bench-marking of cross-sections and spectra of the secondary electrons 
      shows differences between the codes at atomic level, but such differences are not 
      significant in biophysical modelling at the macromolecular level. 
      Clustered-damage evaluation shows: that a substantial proportion of dose ( 30%) 
      is deposited by low-energy electrons; the majority of DNA damage lesions are of 
      simple type; the complexity of damage increases with increased LET, while the 
      total yield of strand breaks remains constant; and at high LET values nearly 70% 
      of all double-strand breaks are of complex type.
FAU - Nikjoo, H
AU  - Nikjoo H
AD  - MRC, Radiation and Genome Stability Unit, Harwell, Oxfordshire, UK.
FAU - Uehara, S
AU  - Uehara S
FAU - Wilson, W E
AU  - Wilson WE
FAU - Hoshi, M
AU  - Hoshi M
FAU - Goodhead, D T
AU  - Goodhead DT
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Int J Radiat Biol
JT  - International journal of radiation biology
JID - 8809243
RN  - 0 (Protons)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Alpha Particles
MH  - Animals
MH  - DNA/radiation effects
MH  - DNA Damage
MH  - Humans
MH  - *Monte Carlo Method
MH  - Protons
MH  - Radiation, Ionizing
MH  - *Radiobiology
RF  - 55
EDAT- 1998/05/20 00:00
MHDA- 1998/05/20 00:01
CRDT- 1998/05/20 00:00
PHST- 1998/05/20 00:00 [pubmed]
PHST- 1998/05/20 00:01 [medline]
PHST- 1998/05/20 00:00 [entrez]
AID - 10.1080/095530098142176 [doi]
PST - ppublish
SO  - Int J Radiat Biol. 1998 Apr;73(4):355-64. doi: 10.1080/095530098142176.