PMID- 9588274
OWN - NLM
STAT- MEDLINE
DCOM- 19980716
LR  - 20200825
IS  - 0304-4602 (Print)
IS  - 0304-4602 (Linking)
VI  - 27
IP  - 1
DP  - 1998 Jan
TI  - The genetics of systemic lupus erythematosus.
PG  - 42-6
AB  - Systemic lupus erythematosus (SLE) is a disease characterised by diverse clinical 
      manifestations and the presence of multiple autoantibodies. There are multiple 
      aetiological factors involved in its pathogenesis. Genetic factors do play an 
      important role and the major histocompatibility complex has been studied 
      extensively and many human leukocyte antigen (HLA) associations have been 
      reported. Twin and familial lupus studies confirm the importance of genetic 
      factors in the development of SLE. Reported HLA associations range from that of 
      HLA-DR3 in Caucasians to HLA-DR2 in Chinese, Japanese and American Blacks. These 
      associations however may only represent linkage disequilibrium and not the actual 
      susceptibility genes. Other non-major histocompatibility complex genes have also 
      been reported to play important roles in the pathogenesis of lupus. The advent of 
      molecular biological techniques has advanced the understanding of susceptibility 
      genes in many diseases. The use of microsatellite genome scanning to study 
      multiplex lupus families has yielded a wealth of information on clusters of 
      susceptibility genes. The identification of these genes will be an important 
      advance in the understanding of this complex disease.
FAU - Fong, K Y
AU  - Fong KY
AD  - Department of Rheumatology and Immunology, Tan Tock Seng Hospital, Singapore.
FAU - Boey, M L
AU  - Boey ML
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Singapore
TA  - Ann Acad Med Singap
JT  - Annals of the Academy of Medicine, Singapore
JID - 7503289
RN  - 0 (Genetic Markers)
RN  - 0 (Immunoglobulins)
SB  - IM
MH  - Animals
MH  - Clinical Trials as Topic
MH  - Disease Susceptibility
MH  - Diseases in Twins/genetics
MH  - Female
MH  - Genetic Counseling
MH  - Genetic Markers
MH  - Genome, Human
MH  - Humans
MH  - Immunoglobulins/genetics
MH  - Linkage Disequilibrium/genetics
MH  - Lupus Erythematosus, Systemic/*genetics
MH  - Major Histocompatibility Complex/genetics
MH  - Male
MH  - Risk Factors
MH  - Singapore
RF  - 62
EDAT- 1998/05/20 00:00
MHDA- 1998/05/20 00:01
CRDT- 1998/05/20 00:00
PHST- 1998/05/20 00:00 [pubmed]
PHST- 1998/05/20 00:01 [medline]
PHST- 1998/05/20 00:00 [entrez]
PST - ppublish
SO  - Ann Acad Med Singap. 1998 Jan;27(1):42-6.