PMID- 9588580
OWN - NLM
STAT- MEDLINE
DCOM- 19980709
LR  - 20131121
IS  - 1053-2498 (Print)
IS  - 1053-2498 (Linking)
VI  - 17
IP  - 4
DP  - 1998 Apr
TI  - Circulating tumor necrosis factor-alpha levels in chronic heart failure: relation 
      to its soluble receptor II, interleukin-6, and neurohumoral variables.
PG  - 356-62
AB  - The cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) 
      are increased in the circulation of patients with chronic heart failure. However, 
      their correlation with left ventricular dysfunction has not yet been thoroughly 
      evaluated, and their interrelation with other neurohumoral systems, such as the 
      adrenergic system and endothelin, is unclear. Therefore TNF-alpha, its soluble 
      receptor II, IL-6, big endothelin, and noradrenaline levels were simultaneously 
      measured in venous blood from 65 patients with heart failure in New York Heart 
      Association (NYHA) class II to IV during therapy with digitalis, furosemide, and 
      enalapril. TNF-alpha plasma levels were 3.2+/-0.2 SEM pg/ml in 38 patients in 
      NYHA function class II, 4.0+/-0.3 SEM pg/ml in 16 patients in NYHA function class 
      III, and 5.3+/-0.9 SEM pg/ml in 11 patients in NYHA function class IV (p < 0.001 
      vs NYHA function class II). IL-6 plasma levels were 3.1+/-0.6 SEM pg/ml in 38 
      patients in NYHA function class II, 5.2+/-0.8 SEM pg/ml in 16 patients in NYHA 
      function class III, and 13.3+/-3.9 SEM pg/ml in 11 patients in NYHA function 
      class IV (p < 0.0001 vs NYHA function class II andp < 0.0001 vs NYHA class III). 
      Thus both cytokines increased with increasing severity of heart failure, but only 
      IL-6 plasma levels were different in patients in the more severe function 
      classes. TNF-alpha correlated closely with TNF soluble receptor II (r = 0.8, p < 
      0.0001) and modestly with serum creatinine (r = 0.6, p < 0.0001), whereas IL-6 
      plasma levels were not statistically related to kidney function. Significant 
      modest correlations were also found among TNF-alpha and IL-6 (r = 0.3, p < 0.01), 
      big endothelin (r = 0.3, p < 0.01), and noradrenaline levels (r = 0.4, <0.001). 
      This study supports the hypothesis that in heart failure both cytokines, 
      TNF-alpha, and IL-6, as well as neurohumoral factors, play a role in the clinical 
      progression of the disease. Thereby levels of TNF-alpha but not IL-6 seem to be 
      related to concomitant kidney dysfunction.
FAU - Koller-Strametz, J
AU  - Koller-Strametz J
AD  - Department of Cardiology, University of Vienna, Austria.
FAU - Pacher, R
AU  - Pacher R
FAU - Frey, B
AU  - Frey B
FAU - Kos, T
AU  - Kos T
FAU - Woloszczuk, W
AU  - Woloszczuk W
FAU - Stanek, B
AU  - Stanek B
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Heart Lung Transplant
JT  - The Journal of heart and lung transplantation : the official publication of the 
      International Society for Heart Transplantation
JID - 9102703
RN  - 0 (Adrenergic Agonists)
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Cardiotonic Agents)
RN  - 0 (Digitalis Glycosides)
RN  - 0 (Diuretics)
RN  - 0 (Endothelin-1)
RN  - 0 (Endothelins)
RN  - 0 (Interleukin-6)
RN  - 0 (Neurotransmitter Agents)
RN  - 0 (Protein Precursors)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 69PN84IO1A (Enalapril)
RN  - 7LXU5N7ZO5 (Furosemide)
RN  - AYI8EX34EU (Creatinine)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Adrenergic Agonists/blood
MH  - Angiotensin-Converting Enzyme Inhibitors/therapeutic use
MH  - Antihypertensive Agents/therapeutic use
MH  - Cardiotonic Agents/therapeutic use
MH  - Chronic Disease
MH  - Creatinine/blood
MH  - Digitalis Glycosides/therapeutic use
MH  - Disease Progression
MH  - Diuretics/therapeutic use
MH  - Enalapril/therapeutic use
MH  - Endothelin-1
MH  - Endothelins/blood
MH  - Female
MH  - Furosemide/therapeutic use
MH  - Heart Failure/*blood/classification/drug therapy
MH  - Humans
MH  - Interleukin-6/*blood
MH  - Kidney/physiopathology
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Neurotransmitter Agents/*blood
MH  - Norepinephrine/blood
MH  - Protein Precursors/blood
MH  - Receptors, Tumor Necrosis Factor/*blood
MH  - Tumor Necrosis Factor-alpha/*analysis
MH  - Ventricular Dysfunction, Left/blood
EDAT- 1998/05/20 00:00
MHDA- 1998/05/20 00:01
CRDT- 1998/05/20 00:00
PHST- 1998/05/20 00:00 [pubmed]
PHST- 1998/05/20 00:01 [medline]
PHST- 1998/05/20 00:00 [entrez]
PST - ppublish
SO  - J Heart Lung Transplant. 1998 Apr;17(4):356-62.