PMID- 9588663
OWN - NLM
STAT- MEDLINE
DCOM- 19980709
LR  - 20191102
IS  - 1071-3581 (Print)
IS  - 1071-3581 (Linking)
VI  - 5
IP  - 2
DP  - 1998 Mar-Apr
TI  - Prediction of functional recovery in acute myocardial infarction: comparison 
      between sestamibi reverse redistribution and sestamibi/BMIPP mismatch.
PG  - 119-27
AB  - BACKGROUND: It has been known that Tc 99m sestamibi/iodine 123 
      betamethyliodophenylpentadecanoic (123I-BMIPP) (sestamibi/BMIPP) mismatch is an 
      indicator of viable myocardium in acute myocardial infarction (AMI). We have 
      reported that reverse redistribution of sestamibi in AMI indicates the patency of 
      infarct-related artery and a preserved left ventricular function in the chronic 
      stage. In this study we investigated the relationship between reverse 
      redistribution of sestamibi and sestamibi/BMIPP mismatch in patients with AMI. 
      METHODS: Twenty-three patients with AMI who received direct percutaneous 
      transluminal coronary angioplasty underwent both BMIPP and sestamibi SPECT within 
      2 weeks after onset. Sestamibi images were obtained 1 hour (early) and 3 hours 
      (delayed) after injection of sestamibi. BMIPP imaging was carried out 30 minutes 
      after injection. The left ventricle was divided into 17 segments, and regional 
      myocardial uptakes of the tracers in each segment were scored from 0 (normal) to 
      3 (no activity). A reverse redistribution pattern was defined as an increase of > 
      or =1 in the regional score at the delayed images. More reduced BMIPP uptake than 
      sestamibi uptake in each segment was determined as sestamibi/BMIPP mismatch. 
      Contrast left ventriculography was performed soon after revascularization and 
      repeated 1 month later. RESULTS: Of 15 patients with sestamibi reverse 
      redistribution, sestamibi/BMIPP mismatch was observed in 14 patients (93%), 
      whereas mismatch was seen in only one of seven patients (14%) without reverse 
      redistribution (p < 0.01). In patients with sestamibi reverse redistribution, 
      regional scores of BMIPP agreed with those of early and delayed images of 
      sestamibi in 51 segments (46%) and in 92 segments (83%), respectively. In the 
      chronic stage, both regional wall motion and left ventricular ejection fraction 
      improved in patients with sestamibi reverse redistribution (wall motion score: 
      6.7 +/- 2.4 vs 2.7 +/- 2.1, p < 0.01; ejection fraction: 56% +/- 7% vs 64% +/- 
      8%, p < 0.01), but not in those without reverse redistribution. CONCLUSION: Both 
      reverse redistribution of sestamibi and sestamibi/BMIPP mismatch reflect the 
      recovery of left ventricular function and thus imply myocardial viability in AMI. 
      Because the presence of reverse redistribution of sestamibi agreed with that of 
      sestamibi/BMIPP mismatch, additional BMIPP images can be replaced by the delayed 
      images after a single injection of sestamibi.
FAU - Fujiwara, S
AU  - Fujiwara S
AD  - First Department of Internal Medicine, Yamagata University School of Medicine, 
      Iida-Nishi, Japan. sfujiwar@med.id.yamagata-u.ac.jp
FAU - Takeishi, Y
AU  - Takeishi Y
FAU - Atsumi, H
AU  - Atsumi H
FAU - Yamaki, M
AU  - Yamaki M
FAU - Takahashi, N
AU  - Takahashi N
FAU - Yamaoka, M
AU  - Yamaoka M
FAU - Tojo, T
AU  - Tojo T
FAU - Tomoike, H
AU  - Tomoike H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Nucl Cardiol
JT  - Journal of nuclear cardiology : official publication of the American Society of 
      Nuclear Cardiology
JID - 9423534
RN  - 0 (Fatty Acids)
RN  - 0 (Iodine Radioisotopes)
RN  - 0 (Iodobenzenes)
RN  - 0 (Radiopharmaceuticals)
RN  - 0J7USQ749M (iodofiltic acid)
RN  - 971Z4W1S09 (Technetium Tc 99m Sestamibi)
SB  - IM
CIN - J Nucl Cardiol. 1998 Mar-Apr;5(2):202-5. PMID: 9588672
MH  - Aged
MH  - Aged, 80 and over
MH  - Angioplasty, Balloon, Coronary
MH  - Coronary Circulation
MH  - *Fatty Acids
MH  - Female
MH  - Heart/diagnostic imaging
MH  - Humans
MH  - *Iodine Radioisotopes
MH  - *Iodobenzenes
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/diagnostic imaging/*physiopathology/therapy
MH  - *Radiopharmaceuticals
MH  - *Technetium Tc 99m Sestamibi
MH  - *Tomography, Emission-Computed, Single-Photon
MH  - Vascular Patency
MH  - Ventricular Function, Left
EDAT- 1998/05/20 00:00
MHDA- 1998/05/20 00:01
CRDT- 1998/05/20 00:00
PHST- 1998/05/20 00:00 [pubmed]
PHST- 1998/05/20 00:01 [medline]
PHST- 1998/05/20 00:00 [entrez]
AID - S1071-3581(98)90194-5 [pii]
AID - 10.1016/s1071-3581(98)90194-5 [doi]
PST - ppublish
SO  - J Nucl Cardiol. 1998 Mar-Apr;5(2):119-27. doi: 10.1016/s1071-3581(98)90194-5.