PMID- 9590831
OWN - NLM
STAT- MEDLINE
DCOM- 19980526
LR  - 20061115
IS  - 0412-4081 (Print)
IS  - 0412-4081 (Linking)
VI  - 32
IP  - 5
DP  - 1996 Sep
TI  - [A study of corneal transplantation and human leukocyte antigen matching].
PG  - 369-71
AB  - OBJECTIVE: The effect of human leukocyte antigen (HLA) matching on immune 
      rejection after keratoplasty was studied. METHODS: Immunoserologic HLA typing was 
      performed on thirty-three eyes with corneal vascularization of 33 high-risk 
      patients before keratoplasty, and HLA matching was made before the surgery. The 
      donor corneas used for these cases were selected on the basis of obtaining a 
      negative HLA cross-match test and matched ABO antigen compatibility of blood 
      group before surgery. The mean follow-up was fifteen months. RESULTS: The 
      findings suggested that there should be highly statistic significance (t = 7.36, 
      P < 0.01) between the rate of rejection of well matched group and that of the 
      poorly matched one. There was no correlation between the number of HLA antigen 
      matched and the rejection rate (t = 0.917, P > 0.05). CONCLUSION: Lower incidence 
      of corneal graft failure from allograft rejection occurs when well HLA matching 
      is used for selecting donor in high-risk patients with corneal vascularization.
FAU - Liu, Y
AU  - Liu Y
AD  - Department of Ophthalmology, Third Clinical College, Bethune University of 
      Medical Sciences, Changchun.
FAU - Zhang, R
AU  - Zhang R
FAU - Guan, L
AU  - Guan L
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Yan Ke Za Zhi
JT  - [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
JID - 16210540R
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Adult
MH  - Corneal Neovascularization/*immunology/surgery
MH  - Female
MH  - Follow-Up Studies
MH  - Graft Rejection
MH  - HLA-A Antigens/blood
MH  - HLA-B Antigens/blood
MH  - HLA-DR Antigens/blood
MH  - *Histocompatibility Testing
MH  - Humans
MH  - *Keratoplasty, Penetrating
MH  - Leukocytes/immunology
MH  - Male
MH  - Middle Aged
EDAT- 1996/09/01 00:00
MHDA- 1998/05/20 00:01
CRDT- 1996/09/01 00:00
PHST- 1996/09/01 00:00 [pubmed]
PHST- 1998/05/20 00:01 [medline]
PHST- 1996/09/01 00:00 [entrez]
PST - ppublish
SO  - Zhonghua Yan Ke Za Zhi. 1996 Sep;32(5):369-71.