PMID- 9591529
OWN - NLM
STAT- MEDLINE
DCOM- 19980602
LR  - 20170214
IS  - 0003-3197 (Print)
IS  - 0003-3197 (Linking)
VI  - 49
IP  - 5
DP  - 1998 May
TI  - Effect of felodipine on arterial blood flow and venous function at rest in 
      patients with mild essential hypertension.
PG  - 373-80
AB  - Felodipine is a second-generation dihydropyridine calcium antagonist used to 
      treat mild to moderate arterial hypertension. The authors used venous occlusion 
      plethysmography to study the effect of this drug on lower limb arterial inflow 
      and venous outflow in 10 at rest patients with mild essential hypertension. They 
      also sought correlations between changes in district blood flow and blood 
      pressure. Plethysmography was carried out at 8 AM and 4, 8, and 24 hours later at 
      baseline (after washout), on the first day of treatment with a single daily 
      administration of 10 mg felodipine ER, and after 7 and 30 days of treatment. The 
      drug was given after the 8 AM evaluation. The authors determined rest flow, 
      maximal venous incremental volume (MVIV) at 40 mmHg and 60 mmHg, and gradient of 
      venous volume between 60 and 40 mmHg divided by the pressure difference (DV/DP) 
      as index of venous distensibility. On the days of plethysmographic evaluation, 
      arterial blood pressure and heart rate were measured continuously over 24 hours 
      by the ABPM (Ambulatory Blood Pressure Monitoring). The results were analyzed by 
      ANOVA. Rest flow, MVIV, and DV/DP were stable at the baseline evaluation. On days 
      1, 7, and 30 of treatment the rest flow after 4 and 8 hours was significantly 
      greater than at 8 AM but had always returned to normal after 24 hours. No other 
      plethysmographic parameters changed significantly; in particular venous outflow 
      remained unchanged. Mean arterial, systolic, and diastolic blood pressure were 
      significantly reduced, compared with baseline, following treatment on the first 
      day and after 7 and 30 days' treatment. There was no effect on heart rate. The 
      authors conclude that felodipine is useful for the treatment of mild essential 
      hypertension, since it reduces arterial resistance without altering venous 
      capacitance or distensibility.
FAU - Bicchi, M
AU  - Bicchi M
AD  - Istituto di Semeiotica Medica e Geriatria, University of Siena, Italy.
FAU - Vedovini, G
AU  - Vedovini G
FAU - Cappelli, R
AU  - Cappelli R
FAU - Arrigucci, S
AU  - Arrigucci S
FAU - Righi, G A
AU  - Righi GA
FAU - Forconi, S
AU  - Forconi S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Angiology
JT  - Angiology
JID - 0203706
RN  - 0 (Calcium Channel Blockers)
RN  - 0 (Vasodilator Agents)
RN  - OL961R6O2C (Felodipine)
SB  - IM
MH  - Aged
MH  - Analysis of Variance
MH  - Blood Pressure/drug effects
MH  - Blood Volume/drug effects
MH  - Calcium Channel Blockers/*therapeutic use
MH  - Diastole
MH  - Felodipine/*therapeutic use
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Rate/drug effects
MH  - Humans
MH  - Hypertension/*drug therapy
MH  - Leg/*blood supply
MH  - Male
MH  - Plethysmography
MH  - Regional Blood Flow/drug effects
MH  - Rest
MH  - Systole
MH  - Vascular Capacitance/drug effects
MH  - Vascular Resistance/drug effects
MH  - Vasodilator Agents/*therapeutic use
EDAT- 1998/05/20 00:00
MHDA- 1998/05/20 00:01
CRDT- 1998/05/20 00:00
PHST- 1998/05/20 00:00 [pubmed]
PHST- 1998/05/20 00:01 [medline]
PHST- 1998/05/20 00:00 [entrez]
AID - 10.1177/000331979804900506 [doi]
PST - ppublish
SO  - Angiology. 1998 May;49(5):373-80. doi: 10.1177/000331979804900506.