PMID- 9592337
OWN - NLM
STAT- MEDLINE
DCOM- 19980605
LR  - 20140226
IS  - 0578-1426 (Print)
IS  - 0578-1426 (Linking)
VI  - 35
IP  - 11
DP  - 1996 Nov
TI  - [The role of human leukocyte antigen in susceptibility and clinical 
      manifestations of sarcoidosis].
PG  - 730-3
AB  - To investigate the association of human leukocyte antigen (HLA) with 
      susceptibility and clinical manifestations of sarcoidosis. Fifty-five patients 
      with sarcoidosis were studied by using allele group specific polymerase chain 
      reaction technique (PCR). Our data show that: (1) the gene frequency of HLA-DR5 
      is significantly increased in patients with sarcoidosis, but that of HLA-DR7 
      decreased. (2) Gene frequencies of HLA-DR9 and HLA-DR5 are relatively increased 
      in male patients and in patients with stage I and stage IIa, respectively. The 
      results suggest that HLA-DR gene might contribute to the susceptibility as well 
      as to the difference of clinical manifestations in sarcoidosis.
FAU - Xu, Z
AU  - Xu Z
AD  - Department of Respiratory Diseases, Peking Union Medical College Hospital, 
      Chinese Academy of Medical Sciences, Beijing.
FAU - Zhu, X
AU  - Zhu X
FAU - Zhao, Y
AU  - Zhao Y
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Nei Ke Za Zhi
JT  - Zhonghua nei ke za zhi
JID - 16210490R
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DR Serological Subtypes)
RN  - 0 (HLA-DR5 Antigen)
RN  - 0 (HLA-DR7 Antigen)
RN  - 0 (HLA-DR9 antigen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Disease Susceptibility
MH  - Female
MH  - Gene Frequency
MH  - HLA Antigens/*genetics
MH  - HLA-DR Antigens/genetics
MH  - HLA-DR Serological Subtypes
MH  - HLA-DR5 Antigen/genetics
MH  - HLA-DR7 Antigen/genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Sarcoidosis/genetics/*immunology
MH  - Sex Factors
EDAT- 1996/11/01 00:00
MHDA- 1998/05/21 00:01
CRDT- 1996/11/01 00:00
PHST- 1996/11/01 00:00 [pubmed]
PHST- 1998/05/21 00:01 [medline]
PHST- 1996/11/01 00:00 [entrez]
PST - ppublish
SO  - Zhonghua Nei Ke Za Zhi. 1996 Nov;35(11):730-3.