PMID- 9593282
OWN - NLM
STAT- MEDLINE
DCOM- 19980529
LR  - 20190914
IS  - 0887-6924 (Print)
IS  - 0887-6924 (Linking)
VI  - 12
IP  - 5
DP  - 1998 May
TI  - The t(6;11)(q27;q23) translocation in acute leukemia: a laboratory and clinical 
      study of 30 cases. EU Concerted Action 11q23 Workshop participants.
PG  - 788-91
AB  - Thirty patients representing 5.5% of those collected by the 11q23 workshop had a 
      t(6;11)(q27;q23). They included 27cases of acute myeloid leukemia (AML) (M1, 
      three cases; M2, two cases; M4, nine cases; M4/M5, one case; M5, 12 cases) of age 
      range 3-72 years and three cases of acute lymphoblastic leukemia (ALL) (B-lineage 
      ALL, two cases; T-ALL, one case) of age range 0.5-13 years. In 20 cases the 
      t(6;11) was the sole abnormality. In 10 cases the recurrent additional 
      abnormalities were extra copies of chromosomes 8, 19, 21, or the der(6). 
      Translocation t(6;11) was identified by cytogenetics alone in 13 cases. In three 
      cases it was confirmed by fluorescence in situ hybridization (FISH) using whole 
      chromosome paints (wcps) 6 and 11. In a further 14 cases involvement of MLL was 
      demonstrated by FISH, by reverse transcriptase polymerase chain reaction 
      (RT-PCR), by Southern blotting (SB) or by a combination of these methods. One 
      case had a direct insertion of 11 into 6-dir ins(6;11)(q27;q13q23). Molecular 
      investigations showed that one case had a 3' deletion of MLL. The median overall 
      survival for the patients was 12 months, indicating a poor prognosis for patients 
      with a t(6;11) translocation.
FAU - Martineau, M
AU  - Martineau M
AD  - Department of Haematology, Royal Free Hospital School of Medicine, London, UK.
FAU - Berger, R
AU  - Berger R
FAU - Lillington, D M
AU  - Lillington DM
FAU - Moorman, A V
AU  - Moorman AV
FAU - Secker-Walker, L M
AU  - Secker-Walker LM
LA  - eng
PT  - Journal Article
PL  - England
TA  - Leukemia
JT  - Leukemia
JID - 8704895
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (KMT2A protein, human)
RN  - 0 (Transcription Factors)
RN  - 149025-06-9 (Myeloid-Lymphoid Leukemia Protein)
RN  - EC 2.1.1.43 (Histone-Lysine N-Methyltransferase)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Blotting, Southern
MH  - Child
MH  - Child, Preschool
MH  - Chromosomes, Human, Pair 11
MH  - *Chromosomes, Human, Pair 6
MH  - DNA-Binding Proteins/genetics
MH  - Female
MH  - Histone-Lysine N-Methyltransferase
MH  - Humans
MH  - Immunophenotyping
MH  - In Situ Hybridization, Fluorescence
MH  - Infant
MH  - Karyotyping
MH  - Leukemia, Myeloid/*genetics
MH  - Leukemia-Lymphoma, Adult T-Cell/*genetics
MH  - Male
MH  - Middle Aged
MH  - Myeloid-Lymphoid Leukemia Protein
MH  - Polymerase Chain Reaction
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics
MH  - *Proto-Oncogenes
MH  - *Transcription Factors
MH  - Transcription, Genetic
MH  - *Translocation, Genetic
EDAT- 1998/05/21 00:00
MHDA- 1998/05/21 00:01
CRDT- 1998/05/21 00:00
PHST- 1998/05/21 00:00 [pubmed]
PHST- 1998/05/21 00:01 [medline]
PHST- 1998/05/21 00:00 [entrez]
AID - 10.1038/sj.leu.2401013 [doi]
PST - ppublish
SO  - Leukemia. 1998 May;12(5):788-91. doi: 10.1038/sj.leu.2401013.