PMID- 9593287
OWN - NLM
STAT- MEDLINE
DCOM- 19980529
LR  - 20190914
IS  - 0887-6924 (Print)
IS  - 0887-6924 (Linking)
VI  - 12
IP  - 5
DP  - 1998 May
TI  - Hematological malignancies with a deletion of 11q23: cytogenetic and clinical 
      aspects. European 11q23 Workshop participants.
PG  - 823-7
AB  - Balanced translocations of 11q23 are associated with specific clinical features 
      and a poor outcome, but the relevance of deletions involving 11q23 is not clear. 
      Fifty-seven patients with this deletion were collected by the Workshop, 30 had 
      terminal and 27 had interstitial deletions. Twenty-seven patients had acute 
      lymphoblastic leukemia (ALL), 16 had acute myeloid leukemia (AML), one had acute 
      biphenotypic leukemia, one had acute undifferentiated leukemia and 12 had 
      myelodysplastic syndrome (MDS). ALL patients had a median age of 7 years, median 
      white blood cell count (WBC) of 15 x 10(9)/l, and 10/24 had common ALL. AML 
      patients had a median age of 23 years, a median WBC of 49 x 10(9)/l, and 9/16 had 
      M4 or M5. MDS patients were all adult, median age of 69 years, median WBC of 3 x 
      10(9)/l, and 7/12 had refractory anemia. The clinical outcome depended on 
      diagnosis: children with ALL had a better prognosis (4/16 relapsed, one died) 
      than AML patients; all adults and children with AML and 5/12 MDS patients died. 
      Fluorescence in situ hybridization (FISH) identified 3 del(11q23) as 
      translocations or insertions. Molecular studies revealed a MLL rearrangement in 
      8/10 patients. Because the involvement of MLL might be of prognostic relevance, 
      identification of a del(11q23) should be an indication for FISH and molecular 
      studies.
FAU - Harbott, J
AU  - Harbott J
AD  - Oncogenetic Laboratory, University Children's Hospital, Giessen, Germany.
FAU - Mancini, M
AU  - Mancini M
FAU - Verellen-Dumoulin, C
AU  - Verellen-Dumoulin C
FAU - Moorman, A V
AU  - Moorman AV
FAU - Secker-Walker, L M
AU  - Secker-Walker LM
LA  - eng
PT  - Journal Article
PL  - England
TA  - Leukemia
JT  - Leukemia
JID - 8704895
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - Child, Preschool
MH  - *Chromosomes, Human, Pair 11
MH  - Female
MH  - *Gene Deletion
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infant
MH  - Karyotyping
MH  - Leukemia, Myeloid/*genetics
MH  - Male
MH  - Middle Aged
MH  - Myelodysplastic Syndromes/*genetics
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics
MH  - Prognosis
EDAT- 1998/05/21 00:00
MHDA- 1998/05/21 00:01
CRDT- 1998/05/21 00:00
PHST- 1998/05/21 00:00 [pubmed]
PHST- 1998/05/21 00:01 [medline]
PHST- 1998/05/21 00:00 [entrez]
AID - 10.1038/sj.leu.2401018 [doi]
PST - ppublish
SO  - Leukemia. 1998 May;12(5):823-7. doi: 10.1038/sj.leu.2401018.