PMID- 9593392
OWN - NLM
STAT- MEDLINE
DCOM- 19980521
LR  - 20220310
IS  - 0161-6420 (Print)
IS  - 1549-4713 (Electronic)
IS  - 0161-6420 (Linking)
VI  - 105
IP  - 5
DP  - 1998 May
TI  - Effect of optic nerve head drusen on nerve fiber layer thickness.
PG  - 878-85
AB  - OBJECTIVE: The purpose of the study was to evaluate the effect of optic nerve 
      head drusen (ONHD) on nerve fiber layer (NFL) thickness by visual field testing, 
      red-free photography of NFL, and optical coherence tomography (OCT). DESIGN: The 
      study design was a prospective clinical study. PARTICIPANTS: Twenty-three eyes of 
      15 consecutive patients with ONHD and 27 eyes of 27 age-matched control subjects 
      participated. INTERVENTION: Ophthalmologic examination, color and red-free 
      photography, automated Humphrey visual field testing, and OCT were performed. 
      Each of the drusen study eyes were graded on a scale of 0 to III based on the 
      amount of visible ONHD. Grade 0 represented the absence of clinically visible 
      ONHD, and grade III represented an optic nerve head with abundant drusen. MAIN 
      OUTCOME MEASURES: Findings from clinical evaluation and color optic nerve head 
      photographs and NFL evaluation by red-free photography, visual fields, and OCT 
      were measured. RESULTS: The number of study eyes with visual field defects 
      increased with the higher grade drusen discs, corresponding both with 
      progressively thinner NFL measurements by OCT and NFL loss shown by NFL 
      photography. The NFL evaluation showed NFL thinning by red-free photography in 12 
      (71%) of 17 eyes with visible drusen (grades I-III discs) and visual field 
      defects in 9 (53%) of 17 eyes in this group. By OCT measurements, the superior 
      and inferior NFLs were significantly thinner in the eyes with visible ONHD 
      compared with those of control eyes in the superior quadrant (P < 0.001) and 
      inferior quadrant (P = 0.004). Compared with grade 0 discs, grades I through III 
      discs showed statistically significant thinning of the NFL superiorly (P < 
      0.001). No statistical significant thinning of the NFL was seen in grade 0 discs 
      compared with those of control subjects. CONCLUSIONS: Optical coherence 
      tomography is able to detect NFL thinning in eyes with ONHD and appears to be a 
      sensitive and early indicator of NFL thinning. Increased numbers of clinically 
      visible ONHD correlated with NFL thinning shown by OCT measurements and both 
      visual field defects and NFL loss seen by red-free photography.
FAU - Roh, S
AU  - Roh S
AD  - New England Eye Center, Tufts University School of Medicine, Boston, 
      Massachusetts 02111, USA.
FAU - Noecker, R J
AU  - Noecker RJ
FAU - Schuman, J S
AU  - Schuman JS
FAU - Hedges, T R 3rd
AU  - Hedges TR 3rd
FAU - Weiter, J J
AU  - Weiter JJ
FAU - Mattox, C
AU  - Mattox C
LA  - eng
GR  - R01 EY011289-14/EY/NEI NIH HHS/United States
GR  - R29 EY011006-05/EY/NEI NIH HHS/United States
GR  - 9-R01-EY11289/EY/NEI NIH HHS/United States
GR  - 5-R29-EY11006-03/EY/NEI NIH HHS/United States
GR  - R01 EY011289/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Ophthalmology
JT  - Ophthalmology
JID - 7802443
SB  - IM
MH  - Female
MH  - Fundus Oculi
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/*pathology
MH  - Optic Disk Drusen/*pathology
MH  - Optic Nerve/*pathology
MH  - Photography
MH  - Prospective Studies
MH  - Tomography/methods
MH  - Visual Fields
PMC - PMC1937403
MID - NIHMS24602
EDAT- 1998/05/21 02:03
MHDA- 2001/03/28 10:01
PMCR- 2007/08/02
CRDT- 1998/05/21 02:03
PHST- 1998/05/21 02:03 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1998/05/21 02:03 [entrez]
PHST- 2007/08/02 00:00 [pmc-release]
AID - S0161-6420(98)95031-X [pii]
AID - 10.1016/S0161-6420(98)95031-X [doi]
PST - ppublish
SO  - Ophthalmology. 1998 May;105(5):878-85. doi: 10.1016/S0161-6420(98)95031-X.