PMID- 9593939
OWN - NLM
STAT- MEDLINE
DCOM- 19980720
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 792
IP  - 2
DP  - 1998 May 11
TI  - Stimulation of NTS activates NMDA and non-NMDA receptors in rat cardiac vagal 
      neurons in the nucleus ambiguus.
PG  - 277-82
AB  - While it is widely accepted that tonic and reflex changes in cardiac vagal 
      activity play significant roles in cardiovascular function, little is known about 
      the synaptic pathways in the brainstem responsible for the control of cardiac 
      vagal neurons in the nucleus ambiguus (NA). In this study, we identified the 
      principal post-synaptic receptors activated in cardiac vagal neurons upon 
      stimulation of the nucleus tractus solitarius (NTS). Cardiac vagal neurons were 
      identified by the presence of a retrograde fluorescent tracer and were visualized 
      in rat brainstem slices. Perforated patch clamp techniques were used to record 
      post-synaptic currents. NTS stimulation activated glutamatergic currents in 
      cardiac vagal neurons with a typical delay of 8-18 ms. Post-synaptic responses 
      were separated into NMDA and non-NMDA components using 
      D-2-amino-5-phophonovalerate (AP5) and 6-cyano-7-nitroquinoxaline-2, 3-dione 
      (CNQX), respectively. In conclusion, this study characterizes a monosynaptic 
      glutamatergic pathway from NTS that activates NMDA and kainate/AMPA post-synaptic 
      receptors in cardiac vagal neurons.
CI  - Copyright 1998 Elsevier Science B.V.
FAU - Neff, R A
AU  - Neff RA
AD  - Department of Physiology and Biophysics, University of Tennessee, 894 Union Ave., 
      Memphis, TN 38163, USA.
FAU - Mihalevich, M
AU  - Mihalevich M
FAU - Mendelowitz, D
AU  - Mendelowitz D
LA  - eng
GR  - HL 49965/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 6OTE87SCCW (6-Cyano-7-nitroquinoxaline-2,3-dione)
RN  - 76726-92-6 (2-Amino-5-phosphonovalerate)
SB  - IM
MH  - 2-Amino-5-phosphonovalerate/pharmacology
MH  - 6-Cyano-7-nitroquinoxaline-2,3-dione/pharmacology
MH  - Animals
MH  - Excitatory Amino Acid Antagonists/pharmacology
MH  - Excitatory Postsynaptic Potentials/drug effects/physiology
MH  - Heart/*innervation
MH  - Neurons/drug effects/physiology
MH  - Organ Culture Techniques
MH  - Parasympathetic Nervous System/chemistry/cytology/physiology
MH  - Rats
MH  - Receptors, N-Methyl-D-Aspartate/*physiology
MH  - Solitary Nucleus/cytology/*physiology
MH  - Vagus Nerve/*chemistry/cytology/*physiology
EDAT- 1998/06/24 00:00
MHDA- 1998/06/24 00:01
CRDT- 1998/06/24 00:00
PHST- 1998/06/24 00:00 [pubmed]
PHST- 1998/06/24 00:01 [medline]
PHST- 1998/06/24 00:00 [entrez]
AID - S0006-8993(98)00149-8 [pii]
AID - 10.1016/s0006-8993(98)00149-8 [doi]
PST - ppublish
SO  - Brain Res. 1998 May 11;792(2):277-82. doi: 10.1016/s0006-8993(98)00149-8.