PMID- 9594552
OWN - NLM
STAT- MEDLINE
DCOM- 19980721
LR  - 20190921
IS  - 0048-0444 (Print)
IS  - 0048-0444 (Linking)
VI  - 65
IP  - 2
DP  - 1998 Apr
TI  - [Quinolinic acid depolarizes the spinal motoneurons of newborn rats by activating 
      NMDA receptors].
PG  - 161-6
AB  - Quinolinic acid (QA), a tryptophan metabolite, is known to be present in many 
      regions of the mammalian central nervous system (CNS). However, its role is still 
      unclear. In order to evaluate the physiological role of QA in CNS, the present 
      study was undertaken to examine its action on the spinal motoneurons of newborn 
      rats in vitro. It wa found that QA depolarized spinal motoneurons directly. Its 
      potency was the same as that of glutamic acid at the same concentrations. The 
      depolarization induced by QA was strongly inhibited by 
      2-amino-5-phosphonovalerate (AP5), an NMDA receptor antagonist. The effect of 
      quinolinic acid was, on the other hand, not inhibited by 
      6-cyano-7-nitroquinoxaline-2, 3-dione (CNQX), a non-NMDA receptor antagonist, in 
      the presence of glycerine. These results indicate that the NMDA receptor is 
      responsible for the QA-induced-depolarization. The possible role of QA as a 
      transmitter is discussed.
FAU - Mizuno, S
AU  - Mizuno S
AD  - Department of Pharmacology, Nippon Medical School, Tokyo, Japan.
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Nihon Ika Daigaku Zasshi
JT  - Nihon Ika Daigaku zasshi
JID - 7505726
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (Neuromuscular Depolarizing Agents)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 76726-92-6 (2-Amino-5-phosphonovalerate)
RN  - F6F0HK1URN (Quinolinic Acid)
RN  - I38ZP9992A (Magnesium)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - 2-Amino-5-phosphonovalerate/pharmacology
MH  - Animals
MH  - Animals, Newborn
MH  - Calcium/physiology
MH  - Dose-Response Relationship, Drug
MH  - Excitatory Amino Acid Antagonists/pharmacology
MH  - In Vitro Techniques
MH  - Magnesium/physiology
MH  - Motor Neurons/*drug effects
MH  - Neuromuscular Depolarizing Agents/*pharmacology
MH  - Quinolinic Acid/*pharmacology/*physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors/*physiology
EDAT- 1998/05/22 00:00
MHDA- 1998/05/22 00:01
CRDT- 1998/05/22 00:00
PHST- 1998/05/22 00:00 [pubmed]
PHST- 1998/05/22 00:01 [medline]
PHST- 1998/05/22 00:00 [entrez]
AID - 10.1272/jnms1923.65.161 [doi]
PST - ppublish
SO  - Nihon Ika Daigaku Zasshi. 1998 Apr;65(2):161-6. doi: 10.1272/jnms1923.65.161.