PMID- 9596001
OWN - NLM
STAT- MEDLINE
DCOM- 19980608
LR  - 20190514
IS  - 0028-3878 (Print)
IS  - 0028-3878 (Linking)
VI  - 50
IP  - 5
DP  - 1998 May
TI  - Role of anticardiolipin antibodies in young persons with migraine and transient 
      focal neurologic events: a prospective study.
PG  - 1433-40
AB  - Anticardiolipin antibodies (aCL) are a risk factor for cerebral ischemia. In 
      migraine, the association is controversial, with widely varying results in 
      different small series. The controversy in part may be due to the inherent 
      difficulty in distinguishing the transient focal neurologic events (TFNE) of 
      migraine from TIA. To assess the frequency of aCL in migraine, we prospectively 
      evaluated consecutive adults under 60 years of age with migraine without aura and 
      with recent TFNE (<24-hour duration) clinically suggestive of either migraine 
      with aura or TIA. We concomitantly enrolled persons with no CNS disease. Each 
      person was interviewed and had blood drawn for solid-phase ELISA with IgG and IgM 
      aCL isotyping. Neuroradiologic studies were reviewed. Patients with TFNE were 
      followed every 6 months for the duration of the 3-year study. The frequency of 
      aCL positivity (IgG >20, IgG >40, IgM >7.5) for the 645 patients with TFNE (8.8, 
      3.1, 4.2%), the 518 persons in the TFNE subgroup with migraine with aura (8.9, 
      3.3, 4.1%), the 497 persons with migraine without aura (7.0, 2.0, 3.6%), and the 
      366 control subjects (9.3, 3.6, 3.9%) did not differ significantly between 
      groups. In TFNE patients with elevated aCL titer, the association was positive 
      with diabetes mellitus, TFNE duration <15 minutes, and diplopia and was negative 
      with hemiparesis, tinnitus, and family history of stroke. Findings on imaging 
      consistent with cerebral ischemia were more frequent in aCL-positive persons. The 
      short-term risk of stroke was uniformly low. In young persons, aCL is not 
      associated with migraine or with TFNE, although diabetes mellitus, negative 
      family history of stroke, and brief duration of symptoms (including diplopia) may 
      predict immunoreactivity. Imaging studies suggest an ischemic etiology of TFNE in 
      this cohort.
FAU - Tietjen, G E
AU  - Tietjen GE
AD  - Neurology Center for Stroke Research, Henry Ford Hospital and Health Sciences 
      Center, Case Western Reserve University, Detroit, MI, USA.
FAU - Day, M
AU  - Day M
FAU - Norris, L
AU  - Norris L
FAU - Aurora, S
AU  - Aurora S
FAU - Halvorsen, A
AU  - Halvorsen A
FAU - Schultz, L R
AU  - Schultz LR
FAU - Levine, S R
AU  - Levine SR
LA  - eng
GR  - NS 23393/NS/NINDS NIH HHS/United States
GR  - NS 30896/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
RN  - 0 (Antibodies, Anticardiolipin)
SB  - IM
CIN - Neurology. 1999 Mar 23;52(5):1107. PMID: 10102449
MH  - Adolescent
MH  - Adult
MH  - Antibodies, Anticardiolipin/*immunology
MH  - Case-Control Studies
MH  - Demography
MH  - Female
MH  - Humans
MH  - Ischemic Attack, Transient/diagnosis/*immunology
MH  - Logistic Models
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Migraine Disorders/*immunology
MH  - Prospective Studies
MH  - Regression Analysis
MH  - Risk Factors
MH  - Tomography, X-Ray Computed
EDAT- 1998/05/22 00:00
MHDA- 1998/05/22 00:01
CRDT- 1998/05/22 00:00
PHST- 1998/05/22 00:00 [pubmed]
PHST- 1998/05/22 00:01 [medline]
PHST- 1998/05/22 00:00 [entrez]
AID - 10.1212/wnl.50.5.1433 [doi]
PST - ppublish
SO  - Neurology. 1998 May;50(5):1433-40. doi: 10.1212/wnl.50.5.1433.