PMID- 9596580
OWN - NLM
STAT- MEDLINE
DCOM- 19980612
LR  - 20190619
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 280
IP  - 5367
DP  - 1998 May 22
TI  - Requirement for gammadelta T cells in allergic airway inflammation.
PG  - 1265-7
AB  - The factors that contribute to allergic asthma are unclear but the resulting 
      condition is considered a consequence of a type-2 T helper (TH2) cell response. 
      In a model of pulmonary allergic inflammation, mice that lacked gammadelta T 
      cells had decreases in specific immunoglobulin E (IgE) and IgG1 and pulmonary 
      interleukin-5 (IL-5) release as well as in eosinophil and T cell infiltration 
      compared with wild-type mice. These responses were restored by administration of 
      IL-4 to gammadelta T cell-deficient mice during the primary immunization. Thus, 
      gammadelta T cells are essential for inducing IL-4-dependent IgE and IgG1 
      responses and for TH2-mediated airway inflammation to peptidic antigens.
FAU - Zuany-Amorim, C
AU  - Zuany-Amorim C
AD  - Unite de Pharmacologie Cellulaire, Unite Associee Institut Pasteur/INSERM U485, 
      Paris, France.
FAU - Ruffie, C
AU  - Ruffie C
FAU - Haile, S
AU  - Haile S
FAU - Vargaftig, B B
AU  - Vargaftig BB
FAU - Pereira, P
AU  - Pereira P
FAU - Pretolani, M
AU  - Pretolani M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Immunoglobulin G)
RN  - 0 (Interleukin-5)
RN  - 0 (Receptors, Antigen, T-Cell, gamma-delta)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 82115-62-6 (Interferon-gamma)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Animals
MH  - Asthma/*immunology
MH  - Bronchi/immunology
MH  - Bronchial Hyperreactivity/immunology
MH  - Bronchoalveolar Lavage Fluid/immunology
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - CD8-Positive T-Lymphocytes/immunology
MH  - Crosses, Genetic
MH  - Eosinophils/immunology
MH  - Female
MH  - Immunization
MH  - Immunoglobulin E/blood
MH  - Immunoglobulin G/blood
MH  - Interferon-gamma/analysis/biosynthesis
MH  - Interleukin-4/biosynthesis/immunology
MH  - Interleukin-5/analysis/biosynthesis
MH  - Lung/*immunology
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Ovalbumin/immunology
MH  - Receptors, Antigen, T-Cell, gamma-delta/*analysis
MH  - T-Lymphocyte Subsets/*immunology
MH  - Th2 Cells/*immunology
EDAT- 1998/06/20 00:00
MHDA- 1998/06/20 00:01
CRDT- 1998/06/20 00:00
PHST- 1998/06/20 00:00 [pubmed]
PHST- 1998/06/20 00:01 [medline]
PHST- 1998/06/20 00:00 [entrez]
AID - 10.1126/science.280.5367.1265 [doi]
PST - ppublish
SO  - Science. 1998 May 22;280(5367):1265-7. doi: 10.1126/science.280.5367.1265.