PMID- 9599408
OWN - NLM
STAT- MEDLINE
DCOM- 19980729
LR  - 20220227
IS  - 1084-9521 (Print)
IS  - 1084-9521 (Linking)
VI  - 9
IP  - 2
DP  - 1998 Apr
TI  - Regulation of G protein signalling in yeast.
PG  - 135-41
AB  - A common property of cell signaling systems is the ability to adapt to chronic 
      stimulation. A genetic analysis of receptor/G protein signaling in yeast has led 
      to the identification of a new class of regulators of G protein signaling (RGS 
      proteins), as well as to new insights about the regulatory role of G protein 
      modifications (myristoylation, palmitoylation). Similar modes of regulation are 
      now known to exist in humans. These discoveries fill some important gaps in our 
      understanding of signal transduction, and provide an instructive example of how 
      model organisms, like yeast, can provide new insights relevant to signal 
      regulation in higher eukaryotes.
FAU - Dohlman, H G
AU  - Dohlman HG
AD  - Department of Pharmacology, Boyer Center for Molecular Medicine, Yale University 
      School of Medicine, New Haven, CT 06536-0812, USA.
FAU - Song, J
AU  - Song J
FAU - Apanovitch, D M
AU  - Apanovitch DM
FAU - DiBello, P R
AU  - DiBello PR
FAU - Gillen, K M
AU  - Gillen KM
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Semin Cell Dev Biol
JT  - Seminars in cell & developmental biology
JID - 9607332
RN  - 0 (GTPase-Activating Proteins)
RN  - 0 (Proteins)
RN  - 0 (ras GTPase-Activating Proteins)
RN  - EC 3.6.1.- (GTP Phosphohydrolases)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
RN  - EC 3.6.5.2 (ras Proteins)
SB  - IM
MH  - Animals
MH  - GTP Phosphohydrolases/physiology
MH  - GTP-Binding Proteins/*physiology
MH  - GTPase-Activating Proteins
MH  - Humans
MH  - Proteins/physiology
MH  - Signal Transduction/*physiology
MH  - Yeasts/*physiology
MH  - ras GTPase-Activating Proteins
MH  - ras Proteins/physiology
RF  - 53
EDAT- 1998/05/26 00:00
MHDA- 1998/05/26 00:01
CRDT- 1998/05/26 00:00
PHST- 1998/05/26 00:00 [pubmed]
PHST- 1998/05/26 00:01 [medline]
PHST- 1998/05/26 00:00 [entrez]
AID - S1084-9521(98)90218-X [pii]
AID - 10.1006/scdb.1998.0218 [doi]
PST - ppublish
SO  - Semin Cell Dev Biol. 1998 Apr;9(2):135-41. doi: 10.1006/scdb.1998.0218.