PMID- 9600213
OWN - NLM
STAT- MEDLINE
DCOM- 19980604
LR  - 20190512
IS  - 0022-3069 (Print)
IS  - 0022-3069 (Linking)
VI  - 57
IP  - 3
DP  - 1998 Mar
TI  - Dystrophic neurites of senile plaques are defective in proteins involved in 
      exocytosis and neurotransmission.
PG  - 218-25
AB  - Dystrophic neurites are major components of neuritic (both immature and mature) 
      senile plaques in Alzheimer disease. Previous studies have shown strong 
      immunoreactivity for different neuropeptides, and chromogranin A, a protein 
      associated with dense-core vesicles, in dystrophic neurites. In the present 
      study, antibodies to synaptophysin, synapsin, Rab3a and synaptotagmin (synaptic 
      vesicle proteins), and SNAP-25 (synaptosomal-associated protein of 25 kD) and 
      syntaxin (presynaptic plasma membrane proteins) have been used to learn about the 
      dystrophic neurite equipment of proteins that are necessary for the docking and 
      fusion of synaptic vesicles, and then for exocytosis and neurotransmission. The 
      present results have shown that, although most neuritic senile plaques have 
      chromogranin A- and SNAP-25-immunoreactive dystrophic neurites, only a percentage 
      of them contain synaptophysin, and a minority contain synaptotagmin and Rab3a. 
      Dystrophic neurites do not contain synapsin and syntaxin. These results show that 
      dystrophic neurites of senile plaques are defective in proteins that control 
      exocytosis and neurotransmission.
FAU - Ferrer, I
AU  - Ferrer I
AD  - Servei d'Anatomia Patologica, Hospital Princeps d'Espanya, Hospitalet de 
      Llobregat, Spain.
FAU - Marti, E
AU  - Marti E
FAU - Tortosa, A
AU  - Tortosa A
FAU - Blasi, J
AU  - Blasi J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Neuropathol Exp Neurol
JT  - Journal of neuropathology and experimental neurology
JID - 2985192R
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Qa-SNARE Proteins)
RN  - 0 (SNAP25 protein, human)
RN  - 0 (Synapsins)
RN  - 0 (Synaptophysin)
RN  - 0 (Synaptosomal-Associated Protein 25)
RN  - 134193-27-4 (Synaptotagmins)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
RN  - EC 3.6.5.2 (rab3 GTP-Binding Proteins)
SB  - IM
MH  - Alzheimer Disease/*metabolism/pathology
MH  - Amyloid beta-Peptides/metabolism
MH  - Blotting, Western
MH  - *Calcium-Binding Proteins
MH  - Exocytosis/*physiology
MH  - GTP-Binding Proteins/metabolism
MH  - Hippocampus/*metabolism/pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Membrane Glycoproteins/metabolism
MH  - Membrane Proteins/metabolism
MH  - Nerve Tissue Proteins/*metabolism
MH  - Neurites/*metabolism/pathology
MH  - Plaque, Amyloid/*metabolism/pathology
MH  - Qa-SNARE Proteins
MH  - Synapsins/metabolism
MH  - Synaptic Transmission/*physiology
MH  - Synaptophysin/metabolism
MH  - Synaptosomal-Associated Protein 25
MH  - Synaptotagmins
MH  - rab3 GTP-Binding Proteins
EDAT- 1998/05/26 00:00
MHDA- 1998/05/26 00:01
CRDT- 1998/05/26 00:00
PHST- 1998/05/26 00:00 [pubmed]
PHST- 1998/05/26 00:01 [medline]
PHST- 1998/05/26 00:00 [entrez]
AID - 10.1097/00005072-199803000-00002 [doi]
PST - ppublish
SO  - J Neuropathol Exp Neurol. 1998 Mar;57(3):218-25. doi: 
      10.1097/00005072-199803000-00002.