PMID- 9601623
OWN - NLM
STAT- MEDLINE
DCOM- 19980807
LR  - 20170214
IS  - 0333-1024 (Print)
IS  - 0333-1024 (Linking)
VI  - 18
IP  - 1
DP  - 1998 Jan
TI  - Ketoprofen (25 mg) in the symptomatic treatment of episodic tension-type 
      headache: double-blind placebo-controlled comparison with acetaminophen (1000 
      mg).
PG  - 38-43
AB  - Therapies in current use for episodic tension-type headache (ETTH) are often 
      unsatisfactory. Few trials have been conducted to demonstrate efficacy of any of 
      them. This multicenter placebo-controlled randomized parallel-groups study 
      compared the analgesic efficacy of single oral doses of ketoprofen 25 mg and 
      acetaminophen 1000 mg as outpatient treatment of 1 attack of ETTH. Efficacy was 
      assessed by patients as pain relief on a diary-entered 7-point categorical scale. 
      A total of 457 patients treated 348 attacks, 330 of which were evaluable. There 
      were no serious adverse events (AEs); gastrointestinal AEs were most common on 
      all treatments. Total relief from pain after 2 h was recorded by 16% of patients 
      on placebo, 28% on ketoprofen, and 22% on acetaminophen. Worthwhile effect or 
      total relief (all other responses were regarded as treatment failures) were 
      recorded by 36% on placebo, 70% on ketoprofen (p < 0.001), 61% on acetaminophen 
      (p < 0.001). The difference between ketoprofen and acetaminophen was not 
      significant (p = 0.24). Various secondary efficacy measures confirmed superiority 
      of both active treatments over placebo, with some trends for slightly better 
      outcome on ketoprofen that on acetaminophen. This study demonstrates that 
      ketoprofen is an effective alternative to standard therapy in ETTH.
FAU - Steiner, T J
AU  - Steiner TJ
AD  - Division of Neuroscience and Psychological Medicine, Imperial College School of 
      Medicine, London, UK. t.steiner@cxwms.ac.uk
FAU - Lange, R
AU  - Lange R
LA  - eng
PT  - Clinical Trial
PT  - Clinical Trial, Phase III
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PL  - England
TA  - Cephalalgia
JT  - Cephalalgia : an international journal of headache
JID - 8200710
RN  - 0 (Analgesics, Non-Narcotic)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 362O9ITL9D (Acetaminophen)
RN  - 90Y4QC304K (Ketoprofen)
SB  - IM
MH  - Acetaminophen/*administration & dosage/adverse effects
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Analgesics, Non-Narcotic/*administration & dosage/adverse effects
MH  - Anti-Inflammatory Agents, Non-Steroidal/*administration & dosage/adverse effects
MH  - Dose-Response Relationship, Drug
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Ketoprofen/*administration & dosage/adverse effects
MH  - Male
MH  - Middle Aged
MH  - Pain Measurement
MH  - Tension-Type Headache/*drug therapy
MH  - Treatment Outcome
EDAT- 1998/05/28 00:00
MHDA- 1998/05/28 00:01
CRDT- 1998/05/28 00:00
PHST- 1998/05/28 00:00 [pubmed]
PHST- 1998/05/28 00:01 [medline]
PHST- 1998/05/28 00:00 [entrez]
AID - 10.1046/j.1468-2982.1998.1801038.x [doi]
PST - ppublish
SO  - Cephalalgia. 1998 Jan;18(1):38-43. doi: 10.1046/j.1468-2982.1998.1801038.x.