PMID- 9604443
OWN - NLM
STAT- MEDLINE
DCOM- 19980623
LR  - 20190512
IS  - 0007-1420 (Print)
IS  - 0007-1420 (Linking)
VI  - 54
IP  - 1
DP  - 1998
TI  - Current regimens for treatment of Helicobacter pylori infection.
PG  - 195-205
AB  - The aim of treatment of Helicobacter pylori is eradication of the bacterium from 
      the foregut. Treatment is difficult because of the bacterium's habitat and 
      acquired resistance to commonly used antibiotics. Dual therapy, the 2 week 
      combination of omeprazole or ranitidine bismuth citrate and either amoxycillin or 
      clarithromycin, eradicates H. pylori in 50-80% of patients. Classical triple 
      therapy is commonly associated with side effects, is highly dependent on 
      patient's compliance, and is significantly less effective in the presence of 
      metronidazole-resistant strains of H. pylori, where eradication may be 50%. One 
      week, twice daily, proton pump inhibitor (PPI)-based triple therapy regimens 
      eradicate about 90% of H. pylori and are associated with mild side effects. 
      Second line regimens include 7 days treatment with omeprazole and 3 times daily 
      amoxycillin and metronidazole or a PPI-based quadruple therapy regimen. In some 
      cases, the bacterium defeats all attempts at eradication.
FAU - Harris, A
AU  - Harris A
AD  - Kent and Sussex Hospital, Royal Tunbridge Wells, UK.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Br Med Bull
JT  - British medical bulletin
JID - 0376542
RN  - 0 (Antitrichomonal Agents)
RN  - 0 (Histamine H2 Antagonists)
RN  - 0 (Proton Pump Inhibitors)
RN  - 804826J2HU (Amoxicillin)
RN  - 884KT10YB7 (Ranitidine)
RN  - H1250JIK0A (Clarithromycin)
RN  - KG60484QX9 (Omeprazole)
SB  - IM
MH  - Amoxicillin/administration & dosage
MH  - Antitrichomonal Agents/*therapeutic use
MH  - Clarithromycin/administration & dosage
MH  - Drug Therapy, Combination/*therapeutic use
MH  - Helicobacter Infections/*drug therapy
MH  - *Helicobacter pylori
MH  - Histamine H2 Antagonists/*therapeutic use
MH  - Humans
MH  - Omeprazole/administration & dosage/therapeutic use
MH  - *Proton Pump Inhibitors
MH  - Ranitidine/therapeutic use
MH  - Stomach Diseases/*drug therapy/microbiology
MH  - Treatment Outcome
RF  - 47
EDAT- 1998/05/30 00:00
MHDA- 1998/05/30 00:01
CRDT- 1998/05/30 00:00
PHST- 1998/05/30 00:00 [pubmed]
PHST- 1998/05/30 00:01 [medline]
PHST- 1998/05/30 00:00 [entrez]
AID - 10.1093/oxfordjournals.bmb.a011670 [doi]
PST - ppublish
SO  - Br Med Bull. 1998;54(1):195-205. doi: 10.1093/oxfordjournals.bmb.a011670.