PMID- 9605339
OWN - NLM
STAT- MEDLINE
DCOM- 19980702
LR  - 20071114
IS  - 1059-910X (Print)
IS  - 1059-910X (Linking)
VI  - 41
IP  - 3
DP  - 1998 May 1
TI  - Differential distribution of NMDA receptor subunit mRNA in the rat cochlear 
      nucleus.
PG  - 217-23
AB  - The distribution and expression of mRNAs for different subunits of the 
      N-methyl-D-aspartate receptor (NMDAR) were examined in the cochlear nucleus (CN) 
      of the rat using radioactive in situ hybridization methods. Heavy labeling for 
      NMDAR1 subunit mRNA was observed in all major CN neuronal types with lower 
      labeling for NMDAR2A, 2B, 2C, and 2D mRNA. Silver grain counting was used to 
      compare expression of different NMDAR2 subunits between six of the major CN cell 
      types. Small cells of the small cell cap/shell area had the highest expression of 
      NMDAR2A-C subunit mRNAs of the cell types assessed. These small cells as well as 
      fusiform and corn cells of the dorsal cochlear nucleus had higher NMDAR2C than 
      other NMDAR2 subunits, providing these neuron types with a distinct expression 
      pattern or profile. The other three cell types assessed, spherical bushy cells, 
      granule cells, and octopus cells had relatively equivalent levels of NMDAR2A-C 
      subunit expressions, providing a second distinct profile. NMDAR2D mRNA had low 
      expression in all six cell types assessed.
FAU - Sato, K
AU  - Sato K
AD  - Kresge Hearing Research Institute, University of Michigan, Ann Arbor 48109-0506, 
      USA.
FAU - Kuriyama, H
AU  - Kuriyama H
FAU - Altschuler, R A
AU  - Altschuler RA
LA  - eng
GR  - DC00383/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Microsc Res Tech
JT  - Microscopy research and technique
JID - 9203012
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
MH  - Animals
MH  - Cochlear Nucleus/*chemistry
MH  - In Situ Hybridization
MH  - Male
MH  - RNA, Messenger/*analysis
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, N-Methyl-D-Aspartate/*analysis/genetics
EDAT- 1998/05/30 02:17
MHDA- 2000/06/22 10:00
CRDT- 1998/05/30 02:17
PHST- 1998/05/30 02:17 [pubmed]
PHST- 2000/06/22 10:00 [medline]
PHST- 1998/05/30 02:17 [entrez]
AID - 10.1002/(SICI)1097-0029(19980501)41:3<217::AID-JEMT5>3.0.CO;2-Q [pii]
AID - 10.1002/(SICI)1097-0029(19980501)41:3<217::AID-JEMT5>3.0.CO;2-Q [doi]
PST - ppublish
SO  - Microsc Res Tech. 1998 May 1;41(3):217-23. doi: 
      10.1002/(SICI)1097-0029(19980501)41:3<217::AID-JEMT5>3.0.CO;2-Q.