PMID- 9605430
OWN - NLM
STAT- MEDLINE
DCOM- 19980608
LR  - 20190623
IS  - 0006-2952 (Print)
IS  - 0006-2952 (Linking)
VI  - 55
IP  - 7
DP  - 1998 Apr 1
TI  - Inhibitory effect of mast cell-mediated immediate-type allergic reactions in rats 
      by spirulina.
PG  - 1071-6
AB  - We investigated the effect of spirulina on mast cell-mediated immediate-type 
      allergic reactions. Spirulina dose-dependently inhibited the systemic allergic 
      reaction induced by compound 48/80 in rats. Spirulina inhibited compound 
      48/80-induced allergic reaction 100% with doses of 100-1000 microg/g body weight, 
      i.p. Spirulina (10-1000 microg/g body weight, i.p.) also significantly inhibited 
      local allergic reaction activated by anti-dinitrophenyl (DNP) IgE. When rats were 
      pretreated with spirulina at a concentration ranging from 0.01 to 1000 microg/g 
      body weight, i.p., the serum histamine levels were reduced in a dose-dependent 
      manner. Spirulina (0.001 to 10 microg/mL) dose-dependently inhibited histamine 
      release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or 
      anti-DNP IgE. The level of cyclic AMP in RPMC, when spirulina (10 microg/mL) was 
      added, transiently and significantly increased about 70-fold at 10 sec compared 
      with that of control cells. Moreover, spirulina (10 microg/mL) had a significant 
      inhibitory effect on anti-DNP IgE-induced tumor necrosis factor-alpha production. 
      These results indicate that spirulina inhibits mast cell-mediated immediate-type 
      allergic reactions in vivo and in vitro.
FAU - Kim, H M
AU  - Kim HM
AD  - Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, 
      Chonbuk, South Korea. hmkim@med.wonkwang.ac.kr
FAU - Lee, E H
AU  - Lee EH
FAU - Cho, H H
AU  - Cho HH
FAU - Moon, Y H
AU  - Moon YH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Biochem Pharmacol
JT  - Biochemical pharmacology
JID - 0101032
RN  - 0 (Bacterial Proteins)
RN  - 0 (Dinitrobenzenes)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - 820484N8I3 (Histamine)
SB  - IM
MH  - Animals
MH  - Bacterial Proteins/*pharmacology
MH  - Cyanobacteria/*chemistry
MH  - Dinitrobenzenes/pharmacology
MH  - Histamine/blood
MH  - Histamine Release/*drug effects
MH  - Hypersensitivity/*metabolism
MH  - Immunoglobulin E/biosynthesis
MH  - Mast Cells/*drug effects/metabolism
MH  - Peritoneal Cavity/cytology
MH  - Rats
MH  - Spirulina
MH  - Tumor Necrosis Factor-alpha/biosynthesis
MH  - p-Methoxy-N-methylphenethylamine/pharmacology
EDAT- 1998/05/30 00:00
MHDA- 1998/05/30 00:01
CRDT- 1998/05/30 00:00
PHST- 1998/05/30 00:00 [pubmed]
PHST- 1998/05/30 00:01 [medline]
PHST- 1998/05/30 00:00 [entrez]
AID - S0006-2952(97)00678-3 [pii]
AID - 10.1016/s0006-2952(97)00678-3 [doi]
PST - ppublish
SO  - Biochem Pharmacol. 1998 Apr 1;55(7):1071-6. doi: 10.1016/s0006-2952(97)00678-3.