PMID- 9605497
OWN - NLM
STAT- MEDLINE
DCOM- 19990107
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 245
IP  - 2
DP  - 1998 Apr 3
TI  - Central administration of a nitric oxide synthase inhibitor causes pressor 
      responses via the sympathetic nervous system and the renin-angiotensin system in 
      Wistar rats.
PG  - 109-12
AB  - The central roles of nitric oxide (NO) in regulations of the blood pressure and 
      heart rate were examined in anesthetized rats. Intracerebroventricular (i.c.v.) 
      injection of Nomega-nitro-L-arginine methyl ester (L-NAME) caused dose-dependent 
      increase in the blood pressure and heart rate. The pressor response of the blood 
      pressure to L-NAME (2 micromol, i.c.v.) was reduced by L-arginine (5 micromol, 
      i.c.v). Pretreatment with a ganglionic blocker, pentolinium (10 mg/kg, i.v.), 
      significantly inhibited both pressor responses induced by L-NAME (2 micromol, 
      i.c.v). The later pressor response of the blood pressure to L-NAME was also 
      inhibited by the angiotensin II AT-1 blocker losartan (10 mg/kg, i.v). These 
      results suggest that the response of the blood pressure to L-NAME is mediated by 
      both the sympathetic nervous system and the renin-angiotensin system.
FAU - Moriguchi, S
AU  - Moriguchi S
AD  - Department of Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka 
      University, Japan.
FAU - Ohzuru, N
AU  - Ohzuru N
FAU - Koga, N
AU  - Koga N
FAU - Honda, K
AU  - Honda K
FAU - Saito, R
AU  - Saito R
FAU - Takano, Y
AU  - Takano Y
FAU - Kamiya, H
AU  - Kamiya H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 953357GACY (Pentolinium Tartrate)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type I)
RN  - EC 1.14.13.39 (Nos1 protein, rat)
RN  - V55S2QJN2X (NG-Nitroarginine Methyl Ester)
SB  - IM
MH  - Animals
MH  - Blood Pressure/*drug effects
MH  - Heart Rate/drug effects
MH  - Injections, Intraventricular
MH  - Male
MH  - NG-Nitroarginine Methyl Ester/administration & dosage
MH  - Nitric Oxide Synthase/*antagonists & inhibitors
MH  - Nitric Oxide Synthase Type I
MH  - Pentolinium Tartrate/administration & dosage
MH  - Rats
MH  - Rats, Wistar
MH  - Renin-Angiotensin System/*drug effects/physiology
MH  - Sympathetic Nervous System/*drug effects/enzymology/physiology
EDAT- 1998/05/30 00:00
MHDA- 1998/05/30 00:01
CRDT- 1998/05/30 00:00
PHST- 1998/05/30 00:00 [pubmed]
PHST- 1998/05/30 00:01 [medline]
PHST- 1998/05/30 00:00 [entrez]
AID - S0304394098001827 [pii]
AID - 10.1016/s0304-3940(98)00182-7 [doi]
PST - ppublish
SO  - Neurosci Lett. 1998 Apr 3;245(2):109-12. doi: 10.1016/s0304-3940(98)00182-7.