PMID- 9605843
OWN - NLM
STAT- MEDLINE
DCOM- 19980611
LR  - 20180214
IS  - 0301-0171 (Print)
IS  - 0301-0171 (Linking)
VI  - 79
IP  - 3-4
DP  - 1997
TI  - Chromosomal mapping of the gene encoding serotonin N-acetyltransferase to rat 
      chromosome 10q32.3 and mouse chromosome 11E2.
PG  - 172-5
AB  - Pineal melatonin is produced during the night. Its nocturnal increase regulates 
      circadian rhythms and the photoperiodic reproductive response. Serotonin is 
      acetylated to N-acetylserotonin by serotonin N-acetyltransferase (SNAT) and then 
      methylated to form melatonin by hydroxyindole-O-methyltransferase (HIOMT). The 
      rhythmicity of melatonin synthesis is regulated by the rhythmic activity of SNAT. 
      Most laboratory mice do not have melatonin because of a genetic defect in the 
      activity of SNAT and/or HIOMT. In a previous study using a recombinant inbred 
      strain, we have found that the locus controlling pineal SNAT activity (Nat4) is 
      located on mouse Chromosome 11. Recently, SNAT has been cloned in the rat. In the 
      present study, the gene encoding SNAT was localized, using a rat cDNA fragment, 
      on rat and mouse chromosomes by direct R-banding fluorescence in situ 
      hybridization (FISH). In addition, using molecular linkage analysis with 
      interspecific backcross mice, a gene encoding SNAT was mapped on a mouse 
      chromosome. The gene encoding SNAT was localized to rat chromosome 10q32.3 and 
      mouse Chromosome 11E2 by FISH. The molecular linkage analysis demonstrated that 
      the gene encoding SNAT maps 1.5 cM distal to D11Mit11. The data suggest that Nat4 
      encodes SNAT. These chromosomal locations are in a region of conserved linkage 
      homology between the two species.
FAU - Yoshimura, T
AU  - Yoshimura T
AD  - Department of Animal Physiology, School of Agricultural Sciences, Nagoya 
      University, Japan. takashiy@nuagr1.agr.nagoya-u.ac.jp
FAU - Nagabukuro, A
AU  - Nagabukuro A
FAU - Matsuda, Y
AU  - Matsuda Y
FAU - Suzuki, T
AU  - Suzuki T
FAU - Kuroiwa, A
AU  - Kuroiwa A
FAU - Iigo, M
AU  - Iigo M
FAU - Namikawa, T
AU  - Namikawa T
FAU - Ebihara, S
AU  - Ebihara S
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Cytogenet Cell Genet
JT  - Cytogenetics and cell genetics
JID - 0367735
RN  - EC 2.3.1.5 (Arylamine N-Acetyltransferase)
SB  - IM
MH  - Animals
MH  - Arylamine N-Acetyltransferase/*genetics
MH  - *Chromosome Mapping
MH  - In Situ Hybridization, Fluorescence
MH  - Mice/*genetics
MH  - Rats/*genetics
EDAT- 1997/01/01 00:00
MHDA- 1998/05/30 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1998/05/30 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - 10.1159/000134713 [doi]
PST - ppublish
SO  - Cytogenet Cell Genet. 1997;79(3-4):172-5. doi: 10.1159/000134713.