PMID- 9605845
OWN - NLM
STAT- MEDLINE
DCOM- 19980611
LR  - 20180214
IS  - 0301-0171 (Print)
IS  - 0301-0171 (Linking)
VI  - 79
IP  - 3-4
DP  - 1997
TI  - Physical and linkage mapping of the bovine bone morphogenetic protein 1 on the 
      evolutionary break region of BTA 8.
PG  - 179-83
AB  - Bone morphogenetic protein 1 (BMP1) has been proposed as a regulatory molecule 
      involved in the binding or activation of other BMP molecules. It has been 
      described as being identical to the enzyme C-proteinase that processes 
      procollagens to fibrillar collagens. A fragment containing an exon of the bovine 
      BMP1 gene was amplified from an adapter-ligated genomic DNA library. The isolated 
      bovine BMP1 fragment was assigned by fluorescence in situ hybridization (FISH) to 
      bovine (BTA) chromosome 8q21, a region containing an evolutionary breakpoint 
      between homology to human (HSA) chromosomes 8 and 9. The assignment to BTA 8 was 
      confirmed by using a hybrid somatic cell panel. The 3' intron region of the 
      amplified genomic BMP1 fragment showed a SSCP polymorphism, and linkage analysis 
      in the International Bovine Reference Panel (IBRP) of families confirmed the 
      boundary position of this gene. The BMP1 gene presents total linkage (theta = 
      0.00, Z = 3.61) with the lipoprotein lipase gene on BTA 8 and HSA 8 and a larger 
      recombination fraction (theta = 0.11, Z = 5.03) with the marker GGTB2 on BTA 8 
      and HSA 9. Physical and genetic mapping of the bovine BMP1 gene contribute to 
      narrow the boundary between the HSA 8 and HSA 9 homology segments on BTA 8 and to 
      the comparative mapping between BTA 8, murine chromosome MMU 14, and HSA 8.
FAU - Martin-Burriel, I
AU  - Martin-Burriel I
AD  - Laboratorio de Genetica Bioquimica, Facultad de Veterinaria, Universidad de 
      Zaragoza, Spain. minma@posta.unizar.es
FAU - Goldammer, T
AU  - Goldammer T
FAU - Elduque, C
AU  - Elduque C
FAU - Lundin, M
AU  - Lundin M
FAU - Barendse, W
AU  - Barendse W
FAU - Zaragoza, P
AU  - Zaragoza P
FAU - Olsaker, I
AU  - Olsaker I
LA  - eng
SI  - GENBANK/Y14605
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Cytogenet Cell Genet
JT  - Cytogenetics and cell genetics
JID - 0367735
RN  - 0 (Bone Morphogenetic Proteins)
RN  - EC 3.4.24.- (Metalloendopeptidases)
RN  - EC 3.4.24.19 (BMP1 protein, human)
RN  - EC 3.4.24.19 (Bone Morphogenetic Protein 1)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Bone Morphogenetic Protein 1
MH  - Bone Morphogenetic Proteins/*genetics
MH  - Cattle
MH  - Chromosome Mapping
MH  - Evolution, Molecular
MH  - In Situ Hybridization, Fluorescence
MH  - Metalloendopeptidases/*genetics
MH  - Molecular Sequence Data
EDAT- 1997/01/01 00:00
MHDA- 1998/05/30 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1998/05/30 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - 10.1159/000134715 [doi]
PST - ppublish
SO  - Cytogenet Cell Genet. 1997;79(3-4):179-83. doi: 10.1159/000134715.