PMID- 9607093
OWN - NLM
STAT- MEDLINE
DCOM- 19980720
LR  - 20051122
IS  - 0001-723X (Print)
IS  - 0001-723X (Linking)
VI  - 41
IP  - 6
DP  - 1997 Dec
TI  - Prevention and treatment of lethal influenza A virus bronchopneumonia in mice by 
      monoclonal antibody against haemagglutinin stem region.
PG  - 337-40
AB  - The protective properties of monoclonal antibody (MoAb) C179 directed to the stem 
      region of haemagglutinin (HA) H2 that possessed fusion-inhibition and unique 
      broad cross-neutralizing activities were examined in a mouse model. The MoAb 
      efficiently protected mice against a lethal challenge with pneumovirulent human 
      (H1) and avian (H2) strains of influenza A virus. Survival rates in mice that 
      received intraperitonealy (i.p.) 1000 micrograms of the MoAb per mouse a day 
      before the virus challenge were 90% for H1 and 100% for H2 strain. The dose of 
      the MoAb of 100 micrograms per mouse significantly decreased mortality in mice. 
      Moreover, the MoAb was also efficient in treatment of lethal bronhopneumonia 
      caused by H2 influenza virus. The survival rate in mice that received 1000 
      micrograms of the MoAb per mouse 2 days after the virus challenge was 90%, while 
      that in the control group was 30% only. These results indicate that the MoAb was 
      effective in protection of animals against lethal influenza A infection without 
      significant difference between H1 and H2 subtypes. The MoAb exerted significant 
      effect in treatment of mice infected with H2 influenza virus. Thus, these data 
      allow to suggest that the stem region of HA might be a potential target for 
      prevention of influenza virus infection and antiviral therapy.
FAU - Lipatov, A S
AU  - Lipatov AS
AD  - D.I. Ivanovsky Institute of Virology, Russian Academy of Medical Sciences, 
      Moscow, Russia.
FAU - Gitelman, A K
AU  - Gitelman AK
FAU - Smirnov YuA
AU  - Smirnov YuA
LA  - eng
PT  - Journal Article
PL  - Slovakia
TA  - Acta Virol
JT  - Acta virologica
JID - 0370401
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Hemagglutinins, Viral)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal/immunology/*therapeutic use
MH  - Bronchopneumonia/prevention & control/*therapy
MH  - Dose-Response Relationship, Immunologic
MH  - Hemagglutinins, Viral/*immunology
MH  - Influenza A virus/*immunology
MH  - Mice
MH  - Orthomyxoviridae Infections/prevention & control/*therapy
MH  - Pneumonia, Viral/prevention & control/*therapy
MH  - Random Allocation
MH  - Time Factors
EDAT- 1998/06/02 00:00
MHDA- 1998/06/02 00:01
CRDT- 1998/06/02 00:00
PHST- 1998/06/02 00:00 [pubmed]
PHST- 1998/06/02 00:01 [medline]
PHST- 1998/06/02 00:00 [entrez]
PST - ppublish
SO  - Acta Virol. 1997 Dec;41(6):337-40.