PMID- 9610695
OWN - NLM
STAT- MEDLINE
DCOM- 19980611
LR  - 20220330
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 82
IP  - 11
DP  - 1998 Jun 1
TI  - The prognostic significance of the biomarkers p21WAF1/CIP1, p53, and bcl-2 in 
      laryngeal squamous cell carcinoma.
PG  - 2159-65
AB  - BACKGROUND: The clinical course of laryngeal squamous cell carcinoma (LSCC) 
      varies considerably among patients. New biologic markers are needed to facilitate 
      the stratification of individual patients within the conventional 
      clinicopathologic stages of LSCC. METHODS: Eighty-three LSCCs from an equal 
      number of patients who received at least 10 years of follow-up were investigated 
      for p53, p21WAF1/CIP1, and bcl-2 protein expression by immunohistochemical 
      techniques. The results were correlated with various clinicopathologic 
      parameters, DNA content, and patient outcome by univariate and multivariate 
      statistical analyses. RESULTS: Stage IV disease, large tumor size (>3 cm), 
      positive lymph node status, extranodal extension, and p53 overexpression (in > 
      75% of cells) correlated significantly with prognosis in univariate analysis. 
      There was no correlation between patient outcome and age, gender, race, 
      histologic differentiation, or expression of bcl-2 or p21WAF1/CIP1. In 
      multivariate analysis, lymph node status and p53 overexpression were the only 
      factors significantly associated with survival. CONCLUSIONS: High p53 expression 
      and positive lymph node status were independent predictors of the outcomes of 
      patients with LSCC. These factors may assist in prognostication and better 
      classification of patients for treatment.
FAU - Jin, Y T
AU  - Jin YT
AD  - Department of Pathology, National Chen Kung University Medical Center, Tainan, 
      Taiwan.
FAU - Kayser, S
AU  - Kayser S
FAU - Kemp, B L
AU  - Kemp BL
FAU - Ordonez, N G
AU  - Ordonez NG
FAU - Tucker, S L
AU  - Tucker SL
FAU - Clayman, G L
AU  - Clayman GL
FAU - Goepfert, H
AU  - Goepfert H
FAU - Luna, M A
AU  - Luna MA
FAU - Batsakis, J G
AU  - Batsakis JG
FAU - El-Naggar, A K
AU  - El-Naggar AK
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
RN  - 0 (CDKN1A protein, human)
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p21)
RN  - 0 (Cyclins)
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
RN  - 0 (Tumor Suppressor Protein p53)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/*chemistry/pathology
MH  - Cyclin-Dependent Kinase Inhibitor p21
MH  - Cyclins/*analysis
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Laryngeal Neoplasms/*chemistry/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Prognosis
MH  - Proto-Oncogene Proteins c-bcl-2/*analysis
MH  - Tumor Suppressor Protein p53/*analysis
EDAT- 1998/06/04 02:06
MHDA- 2000/06/20 09:00
CRDT- 1998/06/04 02:06
PHST- 1998/06/04 02:06 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1998/06/04 02:06 [entrez]
AID - 10.1002/(SICI)1097-0142(19980601)82:11<2159::AID-CNCR10>3.0.CO;2-T [pii]
PST - ppublish
SO  - Cancer. 1998 Jun 1;82(11):2159-65.