PMID- 9612002
OWN - NLM
STAT- MEDLINE
DCOM- 19980616
LR  - 20170214
IS  - 0954-4119 (Print)
IS  - 0954-4119 (Linking)
VI  - 212
IP  - 2
DP  - 1998
TI  - Bioactive bone cements.
PG  - 113-20
AB  - Poly(methylmethacrylate) (PMMA) bone cement, used to fix implants into the bone, 
      produces good surgical results if used correctly. However, prostheses do 
      eventually become loose and the breakdown of the cement mantle is a factor in 
      this failure. Limitations of PMMA cement, which lead to problems with the 
      fixation of the implant, include its mechanical characteristics and its influence 
      upon surrounding bone, associated with the polymerization reaction. A bioactive 
      bone cement is particularly designed to produce a better interface between the 
      cement and bone. However, an improvement in mechanical properties, especially 
      fatigue, creep and fracture toughness, are an added necessary requirement to 
      increase the lifetime of a cemented implant. The development of a bioactive 
      cement has been conducted mainly in two ways; firstly, to improve existing PMMA 
      cement by the addition of various bioactive agents and secondly, to design an 
      alternative matrix for the bioactive material to be combined with. The most 
      promising investigations which have been conducted, along with their relative 
      benefits and drawbacks, are discussed.
FAU - Harper, E J
AU  - Harper EJ
AD  - Interdisciplinary Research Centre in Biomedical Materials, Queen Mary and 
      Westfield College, University of London.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Proc Inst Mech Eng H
JT  - Proceedings of the Institution of Mechanical Engineers. Part H, Journal of 
      engineering in medicine
JID - 8908934
RN  - 0 (Biocompatible Materials)
RN  - 0 (Bone Cements)
RN  - 0 (Hydroxyapatites)
RN  - 454I75YXY0 (Bisphenol A-Glycidyl Methacrylate)
RN  - 9002-72-6 (Growth Hormone)
RN  - 9011-14-7 (Polymethyl Methacrylate)
SB  - IM
MH  - *Biocompatible Materials
MH  - Biomechanical Phenomena
MH  - Bisphenol A-Glycidyl Methacrylate
MH  - *Bone Cements/chemistry
MH  - Bone and Bones/physiology
MH  - Growth Hormone/chemistry
MH  - Hydroxyapatites/chemistry
MH  - Joint Prosthesis
MH  - Materials Testing
MH  - Polymethyl Methacrylate/chemistry
RF  - 48
EDAT- 1998/06/05 00:00
MHDA- 1998/06/05 00:01
CRDT- 1998/06/05 00:00
PHST- 1998/06/05 00:00 [pubmed]
PHST- 1998/06/05 00:01 [medline]
PHST- 1998/06/05 00:00 [entrez]
AID - 10.1243/0954411981533881 [doi]
PST - ppublish
SO  - Proc Inst Mech Eng H. 1998;212(2):113-20. doi: 10.1243/0954411981533881.