PMID- 9613472
OWN - NLM
STAT- MEDLINE
DCOM- 19980728
LR  - 20200409
IS  - 0165-2427 (Print)
IS  - 1873-2534 (Electronic)
IS  - 0165-2427 (Linking)
VI  - 61
IP  - 1
DP  - 1998 Feb 16
TI  - Immune responses in pigs infected with porcine reproductive and respiratory 
      syndrome virus (PRRSV).
PG  - 49-66
AB  - In three successive experiments, the immune functions of pigs persistently 
      infected with the porcine reproductive and respiratory syndrome virus (PRRSV) 
      have been evaluated. Non-specific immune responses were analyzed over a period of 
      12 weeks post-infection (PI). In addition, the capacity of PRRSV-infected pigs to 
      develop an efficient immune response against pseudorabies virus (PRV) 
      glycoproteins and to resist to a subsequent virulent challenge was investigated. 
      Our results demonstrate that PRRSV produced minor effects on the immune system of 
      pigs. The skin delayed type hypersensitivity (DTH) in response to 
      phytohemagglutinine injection was slightly diminished one week after challenge, 
      but was restored thereafter. However, three weeks after the infection, the total 
      white blood cell count, and the number of CD2+, CD8+ and IgM+ cells were 
      enhanced. The increase in numbers of CD8+ cells persisted for three consecutive 
      weeks. Serum immunoglobulins in infected pigs also increased by week 3 PI and up 
      to 8 weeks PI. These results show that PRRSV may have stimulating effects on the 
      pig immune system during the phase of long-lasting infection. After immunization 
      with PRV glycoproteins, the production of anti-PRV antibodies and skin DTH 
      response against PRV glycoproteins were not affected. On the contrary, following 
      a virulent PRV challenge, PRRSV-infected pigs developed a better secondary 
      antibody response and their resistance to the infection was as effective as in 
      control pigs. Taken together, our data do not support a systemic 
      immunosuppressive effect of PRRSV, during the persistent phase of infection. 
      Other mechanisms may therefore apply to explain the emergence of secondary 
      infections in endemically infected herds.
FAU - Albina, E
AU  - Albina E
AD  - Centre National d'Etudes Veterinaires et Alimentaires, Unite de Virologie et 
      Immunologie Porcines, Ploufragan, France. emmanuel.albina.cneva@zoopole.asso.fr
FAU - Piriou, L
AU  - Piriou L
FAU - Hutet, E
AU  - Hutet E
FAU - Cariolet, R
AU  - Cariolet R
FAU - L'Hospitalier, R
AU  - L'Hospitalier R
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Vet Immunol Immunopathol
JT  - Veterinary immunology and immunopathology
JID - 8002006
RN  - 0 (Antibodies, Viral)
RN  - 0 (CD2 Antigens)
RN  - 0 (Immunoglobulin M)
SB  - IM
MH  - Animals
MH  - Antibodies, Viral/*analysis
MH  - Blood Cell Count/veterinary
MH  - CD2 Antigens/immunology
MH  - CD4-CD8 Ratio
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - CD8-Positive T-Lymphocytes/immunology
MH  - Enzyme-Linked Immunosorbent Assay/veterinary
MH  - Hypersensitivity, Delayed/immunology
MH  - Immune System
MH  - Immunoglobulin M/analysis
MH  - Porcine Reproductive and Respiratory Syndrome/*immunology
MH  - Porcine respiratory and reproductive syndrome virus/*immunology/pathogenicity
MH  - Skin/immunology
MH  - Swine/*immunology
MH  - Swine Diseases/*immunology
MH  - Viremia/immunology/veterinary
PMC - PMC7119871
EDAT- 1998/06/05 00:00
MHDA- 1998/06/05 00:01
PMCR- 1998/09/10
CRDT- 1998/06/05 00:00
PHST- 1998/06/05 00:00 [pubmed]
PHST- 1998/06/05 00:01 [medline]
PHST- 1998/06/05 00:00 [entrez]
PHST- 1998/09/10 00:00 [pmc-release]
AID - S0165-2427(97)00134-7 [pii]
AID - 10.1016/s0165-2427(97)00134-7 [doi]
PST - ppublish
SO  - Vet Immunol Immunopathol. 1998 Feb 16;61(1):49-66. doi: 
      10.1016/s0165-2427(97)00134-7.