PMID- 9614639
OWN - NLM
STAT- MEDLINE
DCOM- 19980824
LR  - 20191102
IS  - 1071-5576 (Print)
IS  - 1071-5576 (Linking)
VI  - 5
IP  - 3
DP  - 1998 May-Jun
TI  - A role for hepatocyte growth factor/scatter factor in regulating normal and 
      neoplastic cells of reproductive tissues.
PG  - 114-21
AB  - OBJECTIVE: To review data regarding the expression, function, and signal 
      transduction pathways associated with hepatocyte growth factor/scatter factor 
      (HGF/SF) as related to normal and neoplastic cells of reproductive tissues. 
      METHODS: Studies involving HGF/SF were reviewed and the data were summarized. 
      RESULTS: Hepatocyte growth factor/scatter factor is generally expressed within 
      the stromal components of the testis, prostate, placenta, mammary gland, uterine 
      endometrium, and ovary. The receptor for HGF/SF, c-met, is expressed in the 
      epithelial cells of these tissues. Ligand activation of c-met results in its 
      autotyrosine phosphorylation and the subsequent stimulation of numerous signal 
      transduction pathways. Which pathways are activated determine in part the effect 
      that HGF/SF has on a specific tissue. Hepatocyte growth factor/scatter factor can 
      promote a variety of biologic responses including mitosis, motogenesis (i.e., 
      cell movement), differentiation, and apoptosis. In addition, both HGF/SF and 
      c-met continue to be expressed during the neoplastic transformation of cells from 
      these reproductive tissues. CONCLUSION: Hepatocyte growth factor/scatter factor 
      plays an important role in regulating the physiologic function of several 
      reproductive tissues and may also be involved in the oncogenesis of cells within 
      these tissues.
FAU - Lail-Trecker, M
AU  - Lail-Trecker M
AD  - Department of Obstetrics and Gynecology, University of Connecticut Health Center, 
      Farmington 06030, USA.
FAU - Gulati, R
AU  - Gulati R
FAU - Peluso, J J
AU  - Peluso JJ
LA  - eng
GR  - HD33467-01/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - J Soc Gynecol Investig
JT  - Journal of the Society for Gynecologic Investigation
JID - 9433806
RN  - 67256-21-7 (Hepatocyte Growth Factor)
SB  - IM
MH  - Animals
MH  - Breast Neoplasms/*physiopathology
MH  - Female
MH  - Genital Neoplasms, Female/*physiopathology
MH  - Genital Neoplasms, Male/*physiopathology
MH  - Genitalia, Female/*physiology
MH  - Genitalia, Male/*physiology
MH  - Hepatocyte Growth Factor/*physiology
MH  - Humans
MH  - Male
MH  - Signal Transduction
RF  - 101
EDAT- 1998/06/06 00:00
MHDA- 1998/06/06 00:01
CRDT- 1998/06/06 00:00
PHST- 1998/06/06 00:00 [pubmed]
PHST- 1998/06/06 00:01 [medline]
PHST- 1998/06/06 00:00 [entrez]
AID - S1071-5576(97)00111-1 [pii]
AID - 10.1016/s1071-5576(97)00111-1 [doi]
PST - ppublish
SO  - J Soc Gynecol Investig. 1998 May-Jun;5(3):114-21. doi: 
      10.1016/s1071-5576(97)00111-1.