PMID- 9616350
OWN - NLM
STAT- MEDLINE
DCOM- 19980611
LR  - 20190503
IS  - 1355-6037 (Print)
IS  - 1468-201X (Electronic)
IS  - 1355-6037 (Linking)
VI  - 79
IP  - 4
DP  - 1998 Apr
TI  - Nocturnal desaturation in patients with stable heart failure.
PG  - 394-9
AB  - OBJECTIVE: To determine the prevalence of sleep disordered breathing within a 
      United Kingdom heart failure population. SUBJECTS: 104 patients and 21 matched 
      normal volunteers. METHODS: Overnight home pulse oximetry with simultaneous ECG 
      recording in the patient group; daytime sleepiness was assessed using the Epworth 
      sleepiness scale (ESS); 41 patients underwent polysomnography to assess the 
      validity of oximetry as a screening test for Cheyne-Stokes respiration. RESULTS: 
      Home oximetry was a good screening test for Cheyne-Stokes respiration 
      (specificity 81%, sensitivity 87%). Patients with poorer New York Heart 
      Association (NYHA) classes had higher sleepiness scores (p < 0.005). Twenty three 
      patients had "abnormal" patterns of nocturnal desaturation suggestive of 
      Cheyne-Stokes respiration. The mean (SEM) frequency of dips in Sao2 exceeding 4% 
      was 10.3 (0.9) per hour in the patients and 4.8 (0.6) in normal controls (p < 
      0.005). Ejection fraction correlated negatively with dip frequency (r = -0.5, p < 
      0.005). The patient subgroup with > or = 15 dips/hour had a higher mean (SEM) 
      NYHA class (3.0 (0.2) v 2.3 (0.1), p < 0.05), and experienced more ventricular 
      ectopy (220 (76) v 78 (21) beats/hour, p < 0.05). There was no excess of serious 
      arrhythmia. CONCLUSIONS: Nocturnal desaturation is common in patients with 
      treated heart failure. Low ejection fraction was related to dip frequency. Lack 
      of correlation between dips and ESS suggests that arousal from sleep is more 
      important than hypoxia in the aetiology of daytime sleepiness in heart failure. 
      Overnight oximetry is a useful screening test for Cheyne-Stokes respiration in 
      patients with known heart failure.
FAU - Staniforth, A D
AU  - Staniforth AD
AD  - Department of Cardiovascular Medicine, Queens Medical Centre, Nottingham, UK.
FAU - Kinnear, W J
AU  - Kinnear WJ
FAU - Starling, R
AU  - Starling R
FAU - Cowley, A J
AU  - Cowley AJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - Heart
JT  - Heart (British Cardiac Society)
JID - 9602087
SB  - IM
CIN - Heart. 1998 Dec;80(6):633-4. PMID: 10065042
MH  - Aged
MH  - Cheyne-Stokes Respiration/diagnosis/epidemiology/*etiology
MH  - Electrocardiography, Ambulatory
MH  - Heart Failure/*complications
MH  - Humans
MH  - Middle Aged
MH  - Oximetry
MH  - Polysomnography
MH  - Prevalence
MH  - Sensitivity and Specificity
MH  - Sleep Wake Disorders/etiology
PMC - PMC1728650
EDAT- 1998/06/09 00:00
MHDA- 1998/06/09 00:01
PMCR- 2001/04/01
CRDT- 1998/06/09 00:00
PHST- 1998/06/09 00:00 [pubmed]
PHST- 1998/06/09 00:01 [medline]
PHST- 1998/06/09 00:00 [entrez]
PHST- 2001/04/01 00:00 [pmc-release]
AID - 10.1136/hrt.79.4.394 [doi]
PST - ppublish
SO  - Heart. 1998 Apr;79(4):394-9. doi: 10.1136/hrt.79.4.394.