PMID- 9617328
OWN - NLM
STAT- MEDLINE
DCOM- 19980612
LR  - 20131121
IS  - 0385-0684 (Print)
IS  - 0385-0684 (Linking)
VI  - 25
IP  - 6
DP  - 1998 May
TI  - [Adjuvant chemotherapy with UFT or UFT with OK-432 to patients with gastric and 
      colorectal cancer. Kanto Adjuvant Study Group].
PG  - 887-900
AB  - In Japan, long-term oral therapy with tegafur in combination with 
      immunopotentiators is commonly used as adjuvant therapy after curative resection 
      of gastric or colorectal can for gastric and colorectal cancer. When the outcome 
      was analyzed in terms of the relative performance (R.P.) and the individual dose 
      intensity (I.D.I.) of OK-432, gastric cancer patients with a R.P. of 0.5 or 
      higher tended to have a better survival curve. There were no marked differences 
      in lymphocytes subsets, except that the Leu 7 level at 3 months after gastric 
      cancer resection was significantly higher (p < 0.05) in group B than in group A. 
      Thus, no inhibition of the anticancer effect of UFT was noted during long term 
      combination therapy with UFT and an immunopotentiator as postoperative adjuvant 
      therapy for patients who underwent curative resection of gastric or colorectal 
      cancer. The results suggest that UFT combined with long-term OK-432 maintenance 
      therapy may contribute to improve survival rates in gastric cancer patients.
FAU - Konishi, T
AU  - Konishi T
FAU - Idezuki, Y
AU  - Idezuki Y
FAU - Watanabe, H
AU  - Watanabe H
FAU - Haga, S
AU  - Haga S
FAU - Ushirokouji, Y
AU  - Ushirokouji Y
FAU - Shinohara, K
AU  - Shinohara K
FAU - Shibusawa, M
AU  - Shibusawa M
FAU - Bandai, Y
AU  - Bandai Y
FAU - Hiraishi, M
AU  - Hiraishi M
FAU - Murata, N
AU  - Murata N
FAU - Yabe, K
AU  - Yabe K
FAU - Yamamura, T
AU  - Yamamura T
FAU - Yumoto, S
AU  - Yumoto S
FAU - Gunji, A
AU  - Gunji A
FAU - Nishigaki, M
AU  - Nishigaki M
LA  - jpn
PT  - Clinical Trial
PT  - English Abstract
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PL  - Japan
TA  - Gan To Kagaku Ryoho
JT  - Gan to kagaku ryoho. Cancer & chemotherapy
JID - 7810034
RN  - 0 (Adjuvants, Immunologic)
RN  - 0 (Drug Combinations)
RN  - 0 (UFT(R) drug)
RN  - 1548R74NSZ (Tegafur)
RN  - 39325-01-4 (Picibanil)
RN  - 56HH86ZVCT (Uracil)
SB  - IM
MH  - Adjuvants, Immunologic/administration & dosage
MH  - Antineoplastic Combined Chemotherapy Protocols/*administration & dosage
MH  - Chemotherapy, Adjuvant
MH  - Colonic Neoplasms/mortality/surgery/*therapy
MH  - Disease-Free Survival
MH  - Drug Combinations
MH  - Humans
MH  - Middle Aged
MH  - Picibanil/*administration & dosage
MH  - Rectal Neoplasms/mortality/surgery/*therapy
MH  - Stomach Neoplasms/mortality/surgery/*therapy
MH  - Survival Rate
MH  - Tegafur/administration & dosage/*therapeutic use
MH  - Uracil/administration & dosage/*therapeutic use
EDAT- 1998/06/09 00:00
MHDA- 1998/06/09 00:01
CRDT- 1998/06/09 00:00
PHST- 1998/06/09 00:00 [pubmed]
PHST- 1998/06/09 00:01 [medline]
PHST- 1998/06/09 00:00 [entrez]
PST - ppublish
SO  - Gan To Kagaku Ryoho. 1998 May;25(6):887-900.