PMID- 9617664
OWN - NLM
STAT- MEDLINE
DCOM- 19980813
LR  - 20191102
IS  - 0929-5313 (Print)
IS  - 0929-5313 (Linking)
VI  - 5
IP  - 2
DP  - 1998 May
TI  - Reduction of presynaptic action potentials by PAD: model and experimental study.
PG  - 141-56
AB  - A compartmental model of myelinated nerve fiber was used to show that primary 
      afferent depolarization (PAD), as elicited by axo-axonic synapses, reduces the 
      amplitude of propagating action potentials primarily by interfering with ionic 
      current responsible for the spike regeneration. This reduction adds to the effect 
      of the synaptic shunt, increases with the PAD amplitude, and occurs at 
      significant distances from the synaptic zone. PAD transiently enhances the sodium 
      current activation, which partly accounts for the PAD-induced fiber 
      hyperexcitability, and enhances sodium inactivation on a slower time course, thus 
      reducing the amplitude of action potentials. In vivo, intraaxonal recordings from 
      the intraspinal portion of group I afferent fibers were carried out to verify 
      that depolarizations reduced the amplitude of propagating action potentials as 
      predicted by the model. This article suggests PAD might play a major role in 
      presynaptic inhibition.
FAU - Lamotte D'Incamps, B
AU  - Lamotte D'Incamps B
AD  - URA CNRS 1448, Universite Rene Descartes, Paris, France.
FAU - Meunier, C
AU  - Meunier C
FAU - Monnet, M L
AU  - Monnet ML
FAU - Jami, L
AU  - Jami L
FAU - Zytnicki, D
AU  - Zytnicki D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Comput Neurosci
JT  - Journal of computational neuroscience
JID - 9439510
RN  - 9NEZ333N27 (Sodium)
SB  - IM
MH  - Action Potentials/physiology
MH  - Afferent Pathways/physiology
MH  - Animals
MH  - Electrophysiology
MH  - Humans
MH  - *Models, Neurological
MH  - Presynaptic Terminals/*physiology
MH  - Sodium/physiology
EDAT- 1998/06/09 00:00
MHDA- 1998/06/09 00:01
CRDT- 1998/06/09 00:00
PHST- 1998/06/09 00:00 [pubmed]
PHST- 1998/06/09 00:01 [medline]
PHST- 1998/06/09 00:00 [entrez]
AID - 10.1023/a:1008861815083 [doi]
PST - ppublish
SO  - J Comput Neurosci. 1998 May;5(2):141-56. doi: 10.1023/a:1008861815083.