PMID- 9621193
OWN - NLM
STAT- MEDLINE
DCOM- 19980901
LR  - 20191210
IS  - 1080-6040 (Print)
IS  - 1080-6059 (Electronic)
IS  - 1080-6040 (Linking)
VI  - 4
IP  - 2
DP  - 1998 Apr-Jun
TI  - Haemophilus influenzae invasive disease in the United States, 1994-1995: near 
      disappearance of a vaccine-preventable childhood disease.
PG  - 229-37
AB  - We analyzed national Haemophilus influenzae (Hi) surveillance data from 1994 and 
      1995 to describe the epidemiology of Hi invasive disease among persons of all 
      ages. Serotype data were available for 376 (56%) of 669 reported Hi cases among 
      children aged 4 years or younger; 184 (49%) were H. influenzae type b (Hib). 
      Among children aged 4 or younger, incidence (per 100,000) of all Hi invasive 
      disease was 1.8 in 1994 and 1.6 (p < 0.05) in 1995. Children aged 5 months or 
      younger had the highest average annual incidence rate of Hib invasive disease 
      (2.2 per 100,000); children aged 6 to 11 months had the next highest rate (1.2 
      per 100,000)(p < 0.05). Of 181 children with Hib invasive disease whose age in 
      months was known, 85 (47%) were too young (aged 5 months or younger) to have 
      completed a primary series with an Hib-containing vaccine. Of the 83 children 
      with known vaccination status who were eligible to receive a primary series (aged 
      6 months or older), 52 (63%) were undervaccinated, and the remaining 31 (37%) had 
      completed a primary series in which vaccine failed. Among persons aged 5 years or 
      older with Hi invasive disease, the lowest average annual incidence was among 
      those 20 to 39 years of age (0.15 per 100,000), and the highest was among those 
      aged 80 years or older (2.26 per 100,000). Among persons aged 5 years or older, 
      serotype data were available for 1,372 (71%) of the 1,940 Hi invasive disease 
      cases; 159 (28%) of the 568 Hi cases with known serotype were due to Hib.
FAU - Bisgard, K M
AU  - Bisgard KM
AD  - Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. 
      kmb6@cdc.gov
FAU - Kao, A
AU  - Kao A
FAU - Leake, J
AU  - Leake J
FAU - Strebel, P M
AU  - Strebel PM
FAU - Perkins, B A
AU  - Perkins BA
FAU - Wharton, M
AU  - Wharton M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Emerg Infect Dis
JT  - Emerging infectious diseases
JID - 9508155
RN  - 0 (Haemophilus Vaccines)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Centers for Disease Control and Prevention, U.S.
MH  - Child
MH  - Child, Preschool
MH  - Data Collection
MH  - Disease Notification
MH  - Haemophilus Infections/*epidemiology/ethnology/*prevention & control
MH  - *Haemophilus Vaccines
MH  - *Haemophilus influenzae/classification
MH  - Humans
MH  - Incidence
MH  - Infant
MH  - Middle Aged
MH  - Population Surveillance
MH  - Serotyping
MH  - United States
PMC - PMC2640137
EDAT- 1998/06/11 00:00
MHDA- 1998/06/11 00:01
PMCR- 1998/04/01
CRDT- 1998/06/11 00:00
PHST- 1998/06/11 00:00 [pubmed]
PHST- 1998/06/11 00:01 [medline]
PHST- 1998/06/11 00:00 [entrez]
PHST- 1998/04/01 00:00 [pmc-release]
AID - 10.3201/eid0402.980210 [doi]
PST - ppublish
SO  - Emerg Infect Dis. 1998 Apr-Jun;4(2):229-37. doi: 10.3201/eid0402.980210.