PMID- 9622300
OWN - NLM
STAT- MEDLINE
DCOM- 19980807
LR  - 20221207
IS  - 0918-8959 (Print)
IS  - 0918-8959 (Linking)
VI  - 44
IP  - 6
DP  - 1997 Dec
TI  - Multiple endocrine neoplasia type 1 is not rare in Japan.
PG  - 841-5
AB  - Multiple endocrine neoplasia type 1 (MEN 1) is rarely reported in Japanese and 
      other oriental populations. To examine if there is a racial difference in the 
      prevalence of MEN 1, we initiated extensive work on patients with endocrine 
      tumors for additional lesions, and annual screening of family members of affected 
      patients. In a four-year study, eleven asymptomatic patients were found by family 
      screening, and the number of patients with MEN 1 in our clinics increased from 16 
      to 38. Estimated prevalence of MEN 1 was no less than 0.018/1000. MEN 1 may not 
      be as rare as had been thought in Japanese, and the prevalence of MEN 1 in 
      Japanese would not be significantly different from that of Caucasians. Systemic 
      surveillance and extensive screening of family members are required for early 
      detection and management of patients.
FAU - Katai, M
AU  - Katai M
AD  - Department of Geriatrics, Endocrinology and Metabolism, Shinshu University School 
      of Medicine, Matsumoto, Japan.
FAU - Sakurai, A
AU  - Sakurai A
FAU - Itakura, Y
AU  - Itakura Y
FAU - Ikeo, Y
AU  - Ikeo Y
FAU - Nakajima, K
AU  - Nakajima K
FAU - Hara, M
AU  - Hara M
FAU - Iijima, S
AU  - Iijima S
FAU - Kaneko, T
AU  - Kaneko T
FAU - Kobayashi, M
AU  - Kobayashi M
FAU - Ichikawa, K
AU  - Ichikawa K
FAU - Aizawa, T
AU  - Aizawa T
FAU - Hashizume, K
AU  - Hashizume K
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Endocr J
JT  - Endocrine journal
JID - 9313485
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Asian People/*genetics
MH  - Humans
MH  - Japan/epidemiology
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*epidemiology/genetics
MH  - Pedigree
MH  - Population Surveillance
MH  - Prevalence
EDAT- 1998/06/11 00:00
MHDA- 1998/06/11 00:01
CRDT- 1998/06/11 00:00
PHST- 1998/06/11 00:00 [pubmed]
PHST- 1998/06/11 00:01 [medline]
PHST- 1998/06/11 00:00 [entrez]
AID - 10.1507/endocrj.44.841 [doi]
PST - ppublish
SO  - Endocr J. 1997 Dec;44(6):841-5. doi: 10.1507/endocrj.44.841.