PMID- 9623501
OWN - NLM
STAT- MEDLINE
DCOM- 19980731
LR  - 20190921
IS  - 0891-6934 (Print)
IS  - 0891-6934 (Linking)
VI  - 27
IP  - 4
DP  - 1998
TI  - Anti-neutrophil cytoplasm autoantibodies (ANCA). The need for specific and 
      sensitive assays.
PG  - 231-8
AB  - Anti-neutrophil cytoplasm antibodies (ANCA) are a group of autoantibodies 
      primarily associated with systemic vasculitis. Hitherto, the method of choice for 
      ANCA detection has been indirect immunofluorescence (IIF). By this method two 
      major patterns can be seen: a cytoplasmic pattern (cANCA) or a perinuclear 
      pattern (pANCA). The cANCA pattern is most often caused by antibodies directed 
      against proteinase-3 (PR3) and in rare cases it is caused by anti-myeloperoixdase 
      (MPO) antibodies. The pANCA pattern can de caused by antibodies directed against 
      a large group of proteins i.e. MPO, lactofenin and 
      bactericidal/permeability-increasing protein. Often there is a discrepancy 
      between the results obtained by IIF and those reported from the use of assays 
      with purified antigens. This causes confusion. Until now only anti-PR3 and 
      anti-MPO have been found of any clinical value. Therefore, it would be more 
      proper to use assays with these highly purified antigens instead of an unspecific 
      method like IIF.
FAU - Baslund, B
AU  - Baslund B
AD  - Department of Rheumatology, Hvidovre University Hospital, Rigshospitalet, 
      Copenhagen.
FAU - Petersen, J
AU  - Petersen J
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Autoimmunity
JT  - Autoimmunity
JID - 8900070
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
RN  - EC 1.11.1.7 (Peroxidase)
RN  - EC 3.4.21.- (Serine Endopeptidases)
SB  - IM
MH  - Antibodies, Antineutrophil Cytoplasmic/*analysis
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Fluorescent Antibody Technique, Indirect
MH  - Granulomatosis with Polyangiitis/diagnosis
MH  - Humans
MH  - Immunologic Tests/*methods
MH  - Peroxidase/immunology
MH  - Sensitivity and Specificity
MH  - Serine Endopeptidases/immunology
MH  - Vasculitis/*diagnosis
RF  - 68
EDAT- 1998/06/12 00:00
MHDA- 1998/06/12 00:01
CRDT- 1998/06/12 00:00
PHST- 1998/06/12 00:00 [pubmed]
PHST- 1998/06/12 00:01 [medline]
PHST- 1998/06/12 00:00 [entrez]
AID - 10.3109/08916939808993835 [doi]
PST - ppublish
SO  - Autoimmunity. 1998;27(4):231-8. doi: 10.3109/08916939808993835.