PMID- 9623807
OWN - NLM
STAT- MEDLINE
DCOM- 19980811
LR  - 20190921
IS  - 0145-479X (Print)
IS  - 0145-479X (Linking)
VI  - 30
IP  - 1
DP  - 1998 Feb
TI  - Reactivity of nitric oxide with cytochrome c oxidase: interactions with the 
      binuclear centre and mechanism of inhibition.
PG  - 63-9
AB  - Nitric oxide (NO) has recently been recognized as an important biological 
      mediator that inhibits respiration at cytochrome c oxidase (CcO). This inhibition 
      is reversible and shows competition with oxygen, the Ki being lower at low oxygen 
      concentrations. Although the species that binds NO in turnover has been suggested 
      to contain a partially reduced binuclear center, the exact mechanism of the 
      inhibition is not clear. Recently, rapid (ms) redox reactions of NO with the 
      binuclear center have been reported, e.g., the ejection of an electron to 
      cytochrome a and the depletion of the intermediates P and F. These observations 
      have been rationalized within a scheme in which NO reacts with oxidized CuB 
      leading to the reduction of this metal center and formation of nitrite in a very 
      fast reaction. Electron migration from CuB to other redox sites within the enzyme 
      is proposed to explain the optical transitions observed. The relevance of these 
      reactions to the inhibition of CcO and metabolism of NO are discussed.
FAU - Torres, J
AU  - Torres J
AD  - Department of Biological Sciences, University of Essex, Colchester, United 
      Kingdom.
FAU - Cooper, C E
AU  - Cooper CE
FAU - Sharpe, M
AU  - Sharpe M
FAU - Wilson, M T
AU  - Wilson MT
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - J Bioenerg Biomembr
JT  - Journal of bioenergetics and biomembranes
JID - 7701859
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - EC 1.9.3.1 (Electron Transport Complex IV)
SB  - IM
MH  - Animals
MH  - Electron Transport
MH  - Electron Transport Complex IV/*chemistry/metabolism
MH  - Enzyme Activation
MH  - Humans
MH  - Nitric Oxide/*chemistry/metabolism
RF  - 59
EDAT- 1998/06/12 00:00
MHDA- 1998/06/12 00:01
CRDT- 1998/06/12 00:00
PHST- 1998/06/12 00:00 [pubmed]
PHST- 1998/06/12 00:01 [medline]
PHST- 1998/06/12 00:00 [entrez]
AID - 10.1023/a:1020559528124 [doi]
PST - ppublish
SO  - J Bioenerg Biomembr. 1998 Feb;30(1):63-9. doi: 10.1023/a:1020559528124.