PMID- 9625124
OWN - NLM
STAT- MEDLINE
DCOM- 19980630
LR  - 20220317
IS  - 0002-9270 (Print)
IS  - 0002-9270 (Linking)
VI  - 93
IP  - 5
DP  - 1998 May
TI  - Nocturnal recovery of gastric acid secretion with twice-daily dosing of proton 
      pump inhibitors.
PG  - 763-7
AB  - OBJECTIVES: It is our experience that many patients treated with proton pump 
      inhibitors (PPI) b.i.d. recover acid secretion during the night. Our aim was to 
      assess the efficacy of omeprazole and lansoprazole b.i.d. on nocturnal gastric 
      acidity. METHODS: Three groups were studied with intragastric pH monitoring. 
      Group 1 consisted of 17 patients with gastroesophageal reflux disease (GERD) 
      taking omeprazole 20 mg b.i.d. Group 2 was 16 male volunteers taking omeprazole 
      20 mg b.i.d. and Group 3 comprised 12 volunteers taking lansoprazole 30 mg b.i.d. 
      RESULTS: The percentages of time that subjects had pH < 4 were lower during 
      supine than upright periods in Groups 1 and 3 (P < 0.01). Recovery of nocturnal 
      acid secretion lasting > 1 h, termed acid breakthrough, occurred in three-fourths 
      of all individuals within 12 h from intake of the evening dose of PPI. Median 
      time to acid breakthrough for the whole group was 7.5 h. CONCLUSION: Nocturnal 
      acid breakthrough occurs in a majority of patients and normal volunteers taking 
      PPI b.i.d.
FAU - Peghini, P L
AU  - Peghini PL
AD  - The Esophageal Research Laboratory, Allegheny University Hospitals, Graduate, 
      Philadelphia, Pennsylvania 19146, USA.
FAU - Katz, P O
AU  - Katz PO
FAU - Bracy, N A
AU  - Bracy NA
FAU - Castell, D O
AU  - Castell DO
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Gastroenterol
JT  - The American journal of gastroenterology
JID - 0421030
RN  - 0 (2-Pyridinylmethylsulfinylbenzimidazoles)
RN  - 0 (Anti-Ulcer Agents)
RN  - 0 (Proton Pump Inhibitors)
RN  - 0K5C5T2QPG (Lansoprazole)
RN  - KG60484QX9 (Omeprazole)
SB  - IM
CIN - Am J Gastroenterol. 1999 Feb;94(2):536-7. PMID: 10022667
MH  - 2-Pyridinylmethylsulfinylbenzimidazoles
MH  - Adult
MH  - Aged
MH  - Anti-Ulcer Agents/*therapeutic use
MH  - *Circadian Rhythm
MH  - Female
MH  - Gastric Acid/*metabolism
MH  - Gastric Acidity Determination
MH  - Gastroesophageal Reflux/drug therapy/*physiopathology
MH  - Humans
MH  - Lansoprazole
MH  - Male
MH  - Middle Aged
MH  - Monitoring, Ambulatory
MH  - Omeprazole/*analogs & derivatives/*therapeutic use
MH  - *Proton Pump Inhibitors
EDAT- 1998/06/13 00:00
MHDA- 1998/06/13 00:01
CRDT- 1998/06/13 00:00
PHST- 1998/06/13 00:00 [pubmed]
PHST- 1998/06/13 00:01 [medline]
PHST- 1998/06/13 00:00 [entrez]
AID - S0002927098001014 [pii]
AID - 10.1111/j.1572-0241.1998.221_a.x [doi]
PST - ppublish
SO  - Am J Gastroenterol. 1998 May;93(5):763-7. doi: 10.1111/j.1572-0241.1998.221_a.x.