PMID- 9625815
OWN - NLM
STAT- MEDLINE
DCOM- 19980820
LR  - 20190516
IS  - 1019-6439 (Print)
IS  - 1019-6439 (Linking)
VI  - 13
IP  - 1
DP  - 1998 Jul
TI  - Regulation of insulin-like growth factor (IGF) II and IGF binding protein 3 
      autocrine loop in human PC-3 prostate cancer cells by vitamin D metabolite 
      1,25(OH)2D3 and its analog EB1089.
PG  - 137-43
AB  - Prostate cancer and benign prostate hyperplasia (BPH) are major public health 
      problems. Prostate epithelial cell proliferation is regulated by insulin-like 
      growth factor I (IGF-I) which is mitogenic and anti-apoptotic, and IGF binding 
      protein 3 (IGFBP-3) which is an apoptotic agent in these cells. We demonstrate 
      that the 1,25(OH)2D3 and its analog EB1089-induced growth inhibition was 
      associated with increased IGFBP-3 mRNA abundance, IGFBP-3 mRNA stability, IGFBP-3 
      protein accumulation, and decreased IGF-II gene expression. Anti-IGF-II antibody 
      and exogenous recombinant human IGFBP-3 inhibit PC-3 cell proliferation. The 
      results document the inhibitory effects of 1,25(OH)2D3 and EB1089 on the IGF 
      system of mitogens in prostate cancer cells, and suggest a potential therapeutic 
      use of EB1089 in treatment of BPH and prostate cancer.
FAU - Huynh, H
AU  - Huynh H
AD  - Lady Davis Research Institute of the Jewish General Hospital and Departments of 
      Medicine, McGill University, Montreal, Quebec H3T 1E2, Canada.
FAU - Pollak, M
AU  - Pollak M
FAU - Zhang, J C
AU  - Zhang JC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Greece
TA  - Int J Oncol
JT  - International journal of oncology
JID - 9306042
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 0 (RNA, Messenger)
RN  - 67763-97-7 (Insulin-Like Growth Factor II)
RN  - FXC9231JVH (Calcitriol)
RN  - Q0OZ0D9223 (seocalcitol)
SB  - IM
MH  - Antibodies, Monoclonal
MH  - Antineoplastic Agents/*pharmacology
MH  - Calcitriol/*analogs & derivatives/*pharmacology
MH  - Cell Division/drug effects
MH  - Humans
MH  - Insulin-Like Growth Factor Binding Protein 3/genetics/*metabolism
MH  - Insulin-Like Growth Factor II/*metabolism
MH  - Male
MH  - Prostatic Neoplasms/*metabolism
MH  - RNA, Messenger/metabolism
MH  - Tumor Cells, Cultured
EDAT- 1998/06/19 00:00
MHDA- 1998/06/19 00:01
CRDT- 1998/06/19 00:00
PHST- 1998/06/19 00:00 [pubmed]
PHST- 1998/06/19 00:01 [medline]
PHST- 1998/06/19 00:00 [entrez]
AID - 10.3892/ijo.13.1.137 [doi]
PST - ppublish
SO  - Int J Oncol. 1998 Jul;13(1):137-43. doi: 10.3892/ijo.13.1.137.