PMID- 9626579
OWN - NLM
STAT- MEDLINE
DCOM- 19980916
LR  - 20190826
IS  - 0891-5849 (Print)
IS  - 0891-5849 (Linking)
VI  - 24
IP  - 7-8
DP  - 1998 May
TI  - Superoxide dismutase in patients with chronic hepatitis C virus infection.
PG  - 1235-41
AB  - It has been reported that hepatitis C virus (HCV) may cause oxidative stress in 
      infected cells. Patients with chronic hepatitis C exhibit an increased production 
      of tumor necrosis factor-alpha (TNF alpha), a cytokine that can produce oxidative 
      stress by stimulating the generation of reactive oxygen species (ROS). Cell 
      defense against ROS includes overexpression of Mn-superoxide dismutase (SOD), an 
      inducible mitochondrial enzyme. To investigate cell defense against oxidative 
      stress in HCV infection, we analyzed Mn-SOD mRNA in liver and in peripheral blood 
      mononuclear cells (PBMC) from patients with chronic hepatitis C. Mn-SOD 
      expression in PBMC was significantly increased in patients with HCV infection. 
      Patients with sustained virological and biochemical response after therapy showed 
      significantly lower Mn-SOD than patients with positive viremia. By contrast, 
      Mn-SOD expression was not enhanced in the liver of patients with chronic 
      hepatitis C. The values of Mn-SOD mRNA did not correlate with TNF alpha mRNA 
      expression, viral load, or liver disease activity. Our results indicate that in 
      HCV infection an induction of Mn-SOD was present in PBMC but absent in the liver, 
      suggesting that this organ could be less protected against oxidative damage. 
      Oxidative stress could participate in the pathogenesis of HCV infection.
FAU - Larrea, E
AU  - Larrea E
AD  - Department of Internal Medicine, University Clinic, University of Navarra, 
      Pamplona, Spain.
FAU - Beloqui, O
AU  - Beloqui O
FAU - Munoz-Navas, M A
AU  - Munoz-Navas MA
FAU - Civeira, M P
AU  - Civeira MP
FAU - Prieto, J
AU  - Prieto J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Free Radic Biol Med
JT  - Free radical biology & medicine
JID - 8709159
RN  - 0 (DNA Primers)
RN  - 0 (Free Radicals)
RN  - 0 (RNA, Messenger)
RN  - 0 (RNA, Viral)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Base Sequence
MH  - DNA Primers/genetics
MH  - Female
MH  - Free Radicals/metabolism
MH  - Gene Expression
MH  - Hepacivirus/genetics/isolation & purification
MH  - Hepatitis C, Chronic/blood/*enzymology/genetics
MH  - Humans
MH  - Leukocytes, Mononuclear/enzymology
MH  - Liver/enzymology
MH  - Male
MH  - Middle Aged
MH  - Oxidative Stress
MH  - RNA, Messenger/blood/metabolism
MH  - RNA, Viral/blood/genetics
MH  - Superoxide Dismutase/*genetics
MH  - Tumor Necrosis Factor-alpha/genetics
MH  - Viremia/blood/enzymology/genetics
EDAT- 1998/06/17 00:00
MHDA- 1998/06/17 00:01
CRDT- 1998/06/17 00:00
PHST- 1998/06/17 00:00 [pubmed]
PHST- 1998/06/17 00:01 [medline]
PHST- 1998/06/17 00:00 [entrez]
AID - S0891-5849(97)00437-1 [pii]
AID - 10.1016/s0891-5849(97)00437-1 [doi]
PST - ppublish
SO  - Free Radic Biol Med. 1998 May;24(7-8):1235-41. doi: 
      10.1016/s0891-5849(97)00437-1.