PMID- 9626966
OWN - NLM
STAT- MEDLINE
DCOM- 19980624
LR  - 20190702
IS  - 0027-5107 (Print)
IS  - 0027-5107 (Linking)
VI  - 398
IP  - 1-2
DP  - 1998 Feb 26
TI  - A high yield of translocations parallels the high yield of sister chromatid 
      exchanges in the CHO mutant EM9.
PG  - 67-73
AB  - The fluorescence plus Giemsa (FPG) and fluorescence in situ hybridization (FISH) 
      techniques have been used to determine, respectively, the frequencies of sister 
      chromatid exchanges (SCEs) and stable chromosome aberrations (translocations) 
      induced by different concentrations of BrdU in the Chinese hamster ovary cell 
      mutant EM9 and its parental line AA8. The results indicate that BrdU induced a 
      high frequency of SCEs and translocations in EM9 as compared with AA8, and that 
      the translocation/dicentric ratio was also higher in the mutant cell line than in 
      the parental cell line in both untreated and BrdU-treated cultures. These 
      observations may indicate a possible relationship between the molecular 
      mechanisms involved in the formation of SCEs and translocations.
FAU - Dominguez, I
AU  - Dominguez I
AD  - Department of Cell Biology, Faculty of Biology, University of Sevilla, Spain.
FAU - Daza, P
AU  - Daza P
FAU - Natarajan, A T
AU  - Natarajan AT
FAU - Cortes, F
AU  - Cortes F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Mutat Res
JT  - Mutation research
JID - 0400763
RN  - 0 (Mutagens)
RN  - G34N38R2N1 (Bromodeoxyuridine)
SB  - IM
MH  - Animals
MH  - Bromodeoxyuridine
MH  - CHO Cells
MH  - Cricetinae
MH  - In Situ Hybridization, Fluorescence
MH  - Mutagens
MH  - Mutation
MH  - *Sister Chromatid Exchange
MH  - *Translocation, Genetic
EDAT- 1998/06/17 00:00
MHDA- 1998/06/17 00:01
CRDT- 1998/06/17 00:00
PHST- 1998/06/17 00:00 [pubmed]
PHST- 1998/06/17 00:01 [medline]
PHST- 1998/06/17 00:00 [entrez]
AID - S0027-5107(97)00241-8 [pii]
AID - 10.1016/s0027-5107(97)00241-8 [doi]
PST - ppublish
SO  - Mutat Res. 1998 Feb 26;398(1-2):67-73. doi: 10.1016/s0027-5107(97)00241-8.