PMID- 9627685
OWN - NLM
STAT- MEDLINE
DCOM- 19980625
LR  - 20161021
IS  - 1087-0024 (Print)
IS  - 1087-0024 (Linking)
VI  - 1
IP  - 1
DP  - 1996 Apr
TI  - The concept of multiple vitamin D signaling pathways.
PG  - 10-4
AB  - Nuclear signaling by 1 alpha, 25-dihydroxyvitamin D3 (VD) is mediated by its 
      nuclear receptor (VDR). It is widely accepted that VDR forms heterodimers with 
      retinoid X receptors (RXRs) that bind in 5'-RXR-VDR-3' polarity to response 
      elements formed by direct repeats of hexameric core binding motifs spaced by 
      three nucleotides. This model, however, might be too simple to explain the 
      multiplicity of nuclear signaling by VD. Recently, it was reported that VDR forms 
      homodimers and heterodimers with the nuclear receptors for all-trans retinoic 
      acid and thyroid hormone. All four different VDR complexes bind not only to 
      direct repeats, but also to inverted palindromes; moreover, in heterodimeric 
      complexes VDR can also take the 5' position. Taken together, this discriminates 
      at least seven different types of VDR complexes binding each to two types of 
      response elements. For half of these 14 cases, representative natural VD response 
      elements have already been identified, which demonstrates that nature takes 
      advantage of this concept of diversity. It is our hypothesis that the different 
      physiological functions of VD can be related to different VD signaling pathways. 
      Therefore, the identification of VD analogs that specifically trigger these 
      pathways is the goal of our present and future investigations.
FAU - Carlberg, C
AU  - Carlberg C
AD  - Clinique de Dermatologie, Hopital Cantonal Universitaire, Geneva, Switzerland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - J Investig Dermatol Symp Proc
JT  - The journal of investigative dermatology. Symposium proceedings
JID - 9609059
RN  - 0 (Ligands)
RN  - 0 (Receptors, Calcitriol)
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Animals
MH  - Dimerization
MH  - Humans
MH  - Ligands
MH  - Receptors, Calcitriol/chemistry/physiology
MH  - Vitamin D/analogs & derivatives/*physiology
RF  - 53
EDAT- 1996/04/01 00:00
MHDA- 1998/06/17 00:01
CRDT- 1996/04/01 00:00
PHST- 1996/04/01 00:00 [pubmed]
PHST- 1998/06/17 00:01 [medline]
PHST- 1996/04/01 00:00 [entrez]
PST - ppublish
SO  - J Investig Dermatol Symp Proc. 1996 Apr;1(1):10-4.