PMID- 9628244
OWN - NLM
STAT- MEDLINE
DCOM- 19980910
LR  - 20131121
IS  - 0947-7349 (Print)
IS  - 0947-7349 (Linking)
VI  - 106
IP  - 2
DP  - 1998
TI  - Insulin-like growth factor binding protein-3 levels during early and late 
      follow-up after surgery in acromegalic patients.
PG  - 130-4
AB  - Disease activity in acromegaly is accurately reflected by growth hormone (GH) 
      concentration during oral glucose tolerance test (OGTT) and insulin-like growth 
      factor-I (IGF-I) levels, representing an integrated index of GH activity. This 
      prospective study was performed to evaluate whether plasma IGF binding protein 3 
      (IGFBP-3) might also reflect the hormonal disease activity in pituitary 
      acromegaly after operative treatment during early and late follow-up. Twenty-two 
      acromegalic patients were studied. Data were obtained pre-, intra- and 
      post-operatively in 13 cases. In 9 patients the acromegalic activity was studied 
      only after treatment. The hormonal assessment included repeated blood samples for 
      estimation of IGF-I, IGFBP-3 and repeated OGTTs. In each case 100 sigma g 
      octreotide (Sandostatin lambda, Sandoz, Basel) was injected to test the acute 
      response of GH, IGF-I and IGFBP-3. Intraoperatively, GH levels were estimated to 
      examine acutely the influence of tumour reduction on GH levels. Patients were 
      considered cured when GH levels (GH60min) were less than 2 ng/ml during OGTT 4 
      weeks after surgery. The data outlined that in patients with normalized GH60min 
      levels, normalized IGFBP-3 levels were noticed 4 weeks and 12 months 
      post-operatively. In non-cured patients normalized IGFBP-3 concentrations were 
      found in 11 out of 15 cases in the late post-treatment phase. In contrast only 1 
      of 7 cured patients had persistently elevated IGF-I levels within the first month 
      post-operatively, whereas no case of the non-cured patients had IGF-I values in 
      the normal range. Despite these observations a strong correlation of IGF-I and 
      IGFBP-3 did not exist before one year post-operatively -- either in the cured or 
      in the non-cured patients. Serum IGFBP-3 in patients with pituitary acromegaly 
      does not provide a predictive value of appreciable magnitude concerning cure or 
      non-cure from the disease- whether examined early or late in the post-operative 
      period. Absolute levels of IGFBP-3 may thus cause misinterpretation concerning 
      cure of acromegalics after surgery.
FAU - Charalampaki, P
AU  - Charalampaki P
AD  - Department of Neurosurgery, University of Cologne.
FAU - Hildebrandt, G
AU  - Hildebrandt G
FAU - Schaeffer, H J
AU  - Schaeffer HJ
FAU - Schonau, E
AU  - Schonau E
FAU - Klug, N
AU  - Klug N
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Exp Clin Endocrinol Diabetes
JT  - Experimental and clinical endocrinology & diabetes : official journal, German 
      Society of Endocrinology [and] German Diabetes Association
JID - 9505926
RN  - 0 (Hormones)
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - 9002-72-6 (Growth Hormone)
RN  - RWM8CCW8GP (Octreotide)
SB  - IM
MH  - Acromegaly/*blood/drug therapy/*surgery
MH  - Adult
MH  - Aged
MH  - Female
MH  - Follow-Up Studies
MH  - Glucose Tolerance Test
MH  - Growth Hormone/blood/drug effects
MH  - Hormones/therapeutic use
MH  - Humans
MH  - Insulin-Like Growth Factor Binding Protein 3/*blood/drug effects
MH  - Insulin-Like Growth Factor I/drug effects/metabolism
MH  - Male
MH  - Middle Aged
MH  - Octreotide/therapeutic use
MH  - Postoperative Period
MH  - Prospective Studies
MH  - Time Factors
EDAT- 1998/06/17 00:00
MHDA- 1998/06/17 00:01
CRDT- 1998/06/17 00:00
PHST- 1998/06/17 00:00 [pubmed]
PHST- 1998/06/17 00:01 [medline]
PHST- 1998/06/17 00:00 [entrez]
AID - 10.1055/s-0029-1211964 [doi]
PST - ppublish
SO  - Exp Clin Endocrinol Diabetes. 1998;106(2):130-4. doi: 10.1055/s-0029-1211964.