PMID- 9628469
OWN - NLM
STAT- MEDLINE
DCOM- 19980625
LR  - 20220408
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 84
IP  - 2
DP  - 1998 Apr 15
TI  - Expression of monocyte chemoattractant protein-1 and other beta-chemokines by 
      resident glia and inflammatory cells in multiple sclerosis lesions.
PG  - 238-49
AB  - Beta-chemokines induce the directional migration of monocytes and T lymphocytes 
      and are thus associated with chronic inflammation. Using immunocytochemistry and 
      in situ hybridisation (ISH) techniques, we have examined the expression of the 
      beta-chemokines monocyte chemoattractant protein-1 (MCP-1), macrophage 
      inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES (regulated upon 
      activation, normal T cell expressed and secreted) in post-mortem human brain from 
      multiple sclerosis (MS) cases, at different stages of lesion development. In 
      actively demyelinating MS plaques RANTES expression was restricted to the blood 
      vessel endothelium, perivascular cells and surrounding astrocytes, suggesting a 
      role in the recruitment of inflammatory cells from the circulation. MCP-1 was 
      expressed by astrocytes and macrophages within acute MS lesions, but was 
      restricted to reactive astrocytes in the parenchyma surrounding the lesion. 
      MIP-1alpha was expressed by astrocytes and macrophages within the plaque, while 
      MIP-1beta was expressed by macrophages and microglia within the lesion, and by 
      microglia in surrounding white matter. Glial cells may be stimulated to produce 
      chemokines and continue the local inflammatory response by forming chemotactic 
      gradients to attract T cells and mononuclear phagocytes from the circulation and 
      surrounding tissue.
FAU - Simpson, J E
AU  - Simpson JE
AD  - Department of Biomedical Sciences, Sheffield Hallam University, City Campus, 
      South Yorkshire, UK.
FAU - Newcombe, J
AU  - Newcombe J
FAU - Cuzner, M L
AU  - Cuzner ML
FAU - Woodroofe, M N
AU  - Woodroofe MN
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL3)
RN  - 0 (Chemokine CCL4)
RN  - 0 (Chemokine CCL5)
RN  - 0 (Macrophage Inflammatory Proteins)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Adult
MH  - Central Nervous System/chemistry/immunology/pathology
MH  - Chemokine CCL2/analysis/*genetics
MH  - Chemokine CCL3
MH  - Chemokine CCL4
MH  - Chemokine CCL5/analysis/genetics
MH  - Female
MH  - Gene Expression/immunology
MH  - Humans
MH  - In Situ Hybridization
MH  - Macrophage Inflammatory Proteins/analysis/genetics
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/*immunology/*metabolism
MH  - Neuroglia/chemistry/*immunology/*metabolism
MH  - RNA, Messenger/analysis
EDAT- 1998/06/17 02:07
MHDA- 2000/06/01 09:00
CRDT- 1998/06/17 02:07
PHST- 1998/06/17 02:07 [pubmed]
PHST- 2000/06/01 09:00 [medline]
PHST- 1998/06/17 02:07 [entrez]
AID - S0165-5728(97)00208-7 [pii]
AID - 10.1016/s0165-5728(97)00208-7 [doi]
PST - ppublish
SO  - J Neuroimmunol. 1998 Apr 15;84(2):238-49. doi: 10.1016/s0165-5728(97)00208-7.