PMID- 9628510
OWN - NLM
STAT- MEDLINE
DCOM- 19980710
LR  - 20190826
IS  - 0023-852X (Print)
IS  - 0023-852X (Linking)
VI  - 108
IP  - 6
DP  - 1998 Jun
TI  - Oral leukoplakias show numerical chromosomal aberrations detected by fluorescence 
      in situ hybridization.
PG  - 917-22
AB  - To examine at which stage in the multistep process of head and neck tumorigenesis 
      numerical chromosomal alterations can be detected by fluorescence in situ 
      hybridization (FISH), biopsies and cell smear preparations of clinically healthy 
      oral tissue, premalignant lesions (leukoplakias), and tumors were analyzed by 
      FISH using chromosome-specific centromeric probes. Aberrations found in tumor 
      biopsies and in tumor cell smears consisted of trisomy of chromosomes 1, 7, 10, 
      and 17 and monosomy of chromosomes 1, 7, 9, 10, and 17. In five of eight 
      dysplastic oral leukoplakia biopsies, aberrations were seen consisting of trisomy 
      of chromosome 1, 7, and 17, and monosomy of chromosome 9. No aberrations were 
      found in biopsies of hyperplastic lesions (n = 8), or in oral cell smears of 
      persons at risk. Because numerical chromosomal aberrations seem to be highly 
      specific for malignant cells, FISH may help to identify leukoplakias that have a 
      high risk of malignant conversion.
FAU - Lenz, C F
AU  - Lenz CF
AD  - Department of Otorhinolaryngology, University Hospital, School of Medicine, 
      Heidelberg, Germany.
FAU - Pfuhl, A
AU  - Pfuhl A
FAU - Finckh, M
AU  - Finckh M
FAU - Weidauer, H
AU  - Weidauer H
FAU - Bosch, F X
AU  - Bosch FX
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Biopsy
MH  - Chromosome Aberrations/*diagnosis/genetics
MH  - Chromosome Disorders
MH  - Chromosomes, Human, Pair 1/genetics
MH  - Chromosomes, Human, Pair 10/genetics
MH  - Chromosomes, Human, Pair 17/genetics
MH  - Chromosomes, Human, Pair 7/genetics
MH  - Follow-Up Studies
MH  - Head and Neck Neoplasms/*genetics/pathology
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Leukoplakia/*genetics/pathology
MH  - Middle Aged
EDAT- 1998/06/17 00:00
MHDA- 1998/06/17 00:01
CRDT- 1998/06/17 00:00
PHST- 1998/06/17 00:00 [pubmed]
PHST- 1998/06/17 00:01 [medline]
PHST- 1998/06/17 00:00 [entrez]
AID - 10.1097/00005537-199806000-00023 [doi]
PST - ppublish
SO  - Laryngoscope. 1998 Jun;108(6):917-22. doi: 10.1097/00005537-199806000-00023.