PMID- 9631846
OWN - NLM
STAT- MEDLINE
DCOM- 19980702
LR  - 20190815
IS  - 1523-6838 (Electronic)
IS  - 0272-6386 (Linking)
VI  - 31
IP  - 6
DP  - 1998 Jun
TI  - Postdialysis fatigue: lack of effect of a biocompatible membrane.
PG  - 1007-10
AB  - Tumor necrosis factor-alpha (TNF-alpha) has been shown to have somnogenic 
      properties. Plasma levels of this cytokine have been found to increase 
      significantly during dialysis with a bioincompatible (cuprophane) membrane in 
      patients with postdialysis fatigue (PDF). We conducted a crossover study with 
      random assignment to ascertain whether a biocompatible membrane might attenuate 
      the increase of TNF-alpha and severity of PDF. Sixteen patients on maintenance 
      hemodialysis underwent dialysis with either cuprophane (n = 8) or 
      polymethylmethacrylate (PMMA; n = 8) membranes for 1 week and then switched to 
      the opposite membrane during the second week. Predialysis and postdialysis 
      measurements of plasma TNF-alpha levels were performed during the first and last 
      dialysis treatments of each week. A fatigue score was determined from the sum of 
      duration of fatigue and sleep within 6 hours of the completion of dialysis. 
      TNF-alpha levels increased by an average of 18.3% during dialysis with cuprophane 
      membranes but only 2.4% with PMMA membranes (P = 0.04). Despite this, fatigue 
      scores remained unaltered (approximately 4 of 6). Hence, the biocompatible 
      membrane, PMMA, failed to alleviate PDF. This suggests that dialytic stimulation 
      of TNF-alpha plays no substantial role in the pathogenesis of PDF.
FAU - Sklar, A H
AU  - Sklar AH
AD  - Department of Medicine, United Health Services Hospitals, Binghamton, NY, USA. 
      asklar@juno.com
FAU - Beezhold, D H
AU  - Beezhold DH
FAU - Newman, N
AU  - Newman N
FAU - Hendrickson, T
AU  - Hendrickson T
FAU - Dreisbach, A W
AU  - Dreisbach AW
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Kidney Dis
JT  - American journal of kidney diseases : the official journal of the National Kidney 
      Foundation
JID - 8110075
RN  - 0 (Biocompatible Materials)
RN  - 0 (Membranes, Artificial)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9004-34-6 (Cellulose)
RN  - 9011-14-7 (Polymethyl Methacrylate)
RN  - 9050-09-3 (cuprammonium cellulose)
SB  - IM
MH  - *Biocompatible Materials
MH  - Cellulose/analogs & derivatives
MH  - Cross-Over Studies
MH  - Fatigue/*etiology
MH  - Female
MH  - Humans
MH  - Male
MH  - *Membranes, Artificial
MH  - Middle Aged
MH  - Polymethyl Methacrylate
MH  - Renal Dialysis/*adverse effects/instrumentation
MH  - Tumor Necrosis Factor-alpha/analysis
EDAT- 1998/06/19 00:00
MHDA- 1998/06/19 00:01
CRDT- 1998/06/19 00:00
PHST- 1998/06/19 00:00 [pubmed]
PHST- 1998/06/19 00:01 [medline]
PHST- 1998/06/19 00:00 [entrez]
AID - S0272638698001528 [pii]
AID - 10.1053/ajkd.1998.v31.pm9631846 [doi]
PST - ppublish
SO  - Am J Kidney Dis. 1998 Jun;31(6):1007-10. doi: 10.1053/ajkd.1998.v31.pm9631846.