PMID- 9632244
OWN - NLM
STAT- MEDLINE
DCOM- 19980817
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 60
IP  - 2
DP  - 1998 Jun
TI  - Sexual behavior in male rats after radiofrequency or dopamine-depleting lesions 
      in nucleus accumbens.
PG  - 585-92
AB  - Considerable neurochemical evidence links dopamine (DA) in nucleus accumbens 
      (NAcc) to male sexual behavior. The present experiments were conducted to extend 
      this information to the male's sexual response to remote stimuli from estrous 
      female (noncontact erection; NCE). Male rats were tested for copulation and NCE 
      after either 6-hydroxydopamine (6-OHDA) or radiofrequency (RF) lesions in NAcc). 
      Males with an average 78% depletion of DA in NAcc had a lower incidence of NCE, 
      longer latency to display NCE, and fewer erections. DA-depleted males also had 
      less locomotor activity after injections of d-amphetamine, and reductions in 
      apomorphine-induced yawning, but a normal incidence of penile erection. Males 
      with RF lesions of the NAcc had longer NCE latencies. All males copulated to 
      ejaculation after either 6-OHDA or RF lesions with little or no deficit, although 
      the 6-OHDA-treated males had longer intromission latencies. The NCE deficit 
      supports the hypothesized role of NAcc DA in arousal processes in responding to 
      remote cues from estrous females. The minimal effect of lesions on copulation 
      suggests that the presence of additional proximal stimulation during copulation 
      may overcome the deficits induced by DA depletions or lesions in NAcc.
FAU - Liu, Y C
AU  - Liu YC
AD  - Department of Psychology, and Biobehavioral Sciences Graduate Degree Program, 
      University of Connecticut, Storrs 06269-1020, USA.
FAU - Sachs, B D
AU  - Sachs BD
FAU - Salamone, J D
AU  - Salamone JD
LA  - eng
GR  - HD08933/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Dopamine Agonists)
RN  - 0 (Sympatholytics)
RN  - 8HW4YBZ748 (Oxidopamine)
RN  - N21FAR7B4S (Apomorphine)
RN  - TZ47U051FI (Dextroamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Apomorphine/pharmacology
MH  - Central Nervous System Stimulants/pharmacology
MH  - Copulation/drug effects
MH  - Dextroamphetamine/pharmacology
MH  - Dopamine/*physiology
MH  - Dopamine Agonists/pharmacology
MH  - Female
MH  - Male
MH  - Motor Activity/drug effects
MH  - Nucleus Accumbens/drug effects/*physiology
MH  - Oxidopamine/toxicity
MH  - Penile Erection/drug effects
MH  - Radiation Injuries, Experimental/*psychology
MH  - Radio Waves
MH  - Rats
MH  - Sexual Behavior, Animal/drug effects/*physiology
MH  - Sympatholytics/toxicity
MH  - Yawning/drug effects
EDAT- 1998/06/19 00:00
MHDA- 1998/06/19 00:01
CRDT- 1998/06/19 00:00
PHST- 1998/06/19 00:00 [pubmed]
PHST- 1998/06/19 00:01 [medline]
PHST- 1998/06/19 00:00 [entrez]
AID - S0091-3057(98)00022-7 [pii]
AID - 10.1016/s0091-3057(98)00022-7 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1998 Jun;60(2):585-92. doi: 
      10.1016/s0091-3057(98)00022-7.