PMID- 9632612
OWN - NLM
STAT- MEDLINE
DCOM- 19980709
LR  - 20200724
IS  - 0019-9567 (Print)
IS  - 1098-5522 (Electronic)
IS  - 0019-9567 (Linking)
VI  - 66
IP  - 7
DP  - 1998 Jul
TI  - Low genetic diversity of Haemophilus influenzae type b compared to 
      nonencapsulated H. influenzae in a population in which H. influenzae is highly 
      endemic.
PG  - 3403-9
AB  - Immunization with Haemophilus influenzae type b (Hib) conjugate polysaccharide 
      vaccines has dramatically reduced Hib disease worldwide. As in other populations, 
      nasopharyngeal carriage of Hib declined markedly in Aboriginal infants following 
      vaccination, although carriage has not been entirely eliminated. In this study, 
      we describe the genetic characteristics and the carriage dynamics of longitudinal 
      isolates of Hib, characterized by using several typing methods. In addition, 
      carriage rates of nonencapsulated H. influenzae (NCHi) are high, and concurrent 
      colonization with Hib and NCHi is common; we also observed NCHi isolates which 
      were genetically similar to Hib. There is a continuing need to promote Hib 
      immunization and monitor H. influenzae carriage in populations in which the 
      organism is highly endemic, not least because of the possibility of genetic 
      exchange between Hib and NCHi strains in such populations.
FAU - Smith-Vaughan, H C
AU  - Smith-Vaughan HC
AD  - Menzies School of Health Research, Darwin, Northern Territory, Australia. 
      heidi@menzies.su.edu.au
FAU - Sriprakash, K S
AU  - Sriprakash KS
FAU - Leach, A J
AU  - Leach AJ
FAU - Mathews, J D
AU  - Mathews JD
FAU - Kemp, D J
AU  - Kemp DJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Infect Immun
JT  - Infection and immunity
JID - 0246127
RN  - 804826J2HU (Amoxicillin)
RN  - EC 3.5.2.6 (beta-Lactamases)
SB  - IM
MH  - Amoxicillin/pharmacology
MH  - Bacterial Capsules/physiology
MH  - Genetic Variation
MH  - Haemophilus influenzae/drug effects/*genetics/physiology
MH  - Humans
MH  - Polymerase Chain Reaction
MH  - Vaccination
MH  - beta-Lactamases/biosynthesis
PMC - PMC108359
EDAT- 1998/06/25 00:00
MHDA- 1998/06/25 00:01
PMCR- 1998/07/01
CRDT- 1998/06/25 00:00
PHST- 1998/06/25 00:00 [pubmed]
PHST- 1998/06/25 00:01 [medline]
PHST- 1998/06/25 00:00 [entrez]
PHST- 1998/07/01 00:00 [pmc-release]
AID - 0626 [pii]
AID - 10.1128/IAI.66.7.3403-3409.1998 [doi]
PST - ppublish
SO  - Infect Immun. 1998 Jul;66(7):3403-9. doi: 10.1128/IAI.66.7.3403-3409.1998.