PMID- 9634500
OWN - NLM
STAT- MEDLINE
DCOM- 19980813
LR  - 20200824
IS  - 0002-9297 (Print)
IS  - 1537-6605 (Electronic)
IS  - 0002-9297 (Linking)
VI  - 63
IP  - 1
DP  - 1998 Jul
TI  - Linkage analysis of human leukocyte antigen (HLA) markers in familial psoriasis: 
      strong disequilibrium effects provide evidence for a major determinant in the 
      HLA-B/-C region.
PG  - 191-9
AB  - Although psoriasis is strongly associated with certain human leukocyte antigens 
      (HLAs), evidence for linkage to HLA markers has been limited. The objectives of 
      this study were (1) to provide more definitive evidence for linkage of psoriasis 
      to HLA markers in multiplex families; (2) to compare the major HLA risk alleles 
      in these families with those determined by previous case-control studies; and (3) 
      to localize the gene more precisely. By applying the transmission/disequilibrium 
      test (TDT) and parametric linkage analysis, we found evidence for linkage of 
      psoriasis to HLA-C, -B, -DR, and -DQ, with HLA-B and -C yielding the 
      most-significant results. Linkage was detectable by parametric methods only when 
      marker-trait disequilibrium was considered. Case-control association tests and 
      the TDT identified alleles belonging to the EH57.1 ancestral haplotype as the 
      major risk alleles in our sample. Among individuals carrying recombinant 
      ancestral haplotypes involving EH57. 1, the class I markers were retained 
      selectively among affecteds four times more often than among unaffecteds; among 
      the few affected individuals carrying only the class II alleles from the 
      ancestral haplotype, all but one also carried Cw6. These data show that familial 
      and "sporadic" psoriasis share the same risk alleles. They also illustrate that 
      substantial parametric linkage information can be extracted by accounting for 
      linkage disequilibrium. Finally, they strongly suggest that a major 
      susceptibility gene resides near HLA-C.
FAU - Jenisch, S
AU  - Jenisch S
AD  - Department of Immunology, University of Kiel, Kiel, Germany.
FAU - Henseler, T
AU  - Henseler T
FAU - Nair, R P
AU  - Nair RP
FAU - Guo, S W
AU  - Guo SW
FAU - Westphal, E
AU  - Westphal E
FAU - Stuart, P
AU  - Stuart P
FAU - Kronke, M
AU  - Kronke M
FAU - Voorhees, J J
AU  - Voorhees JJ
FAU - Christophers, E
AU  - Christophers E
FAU - Elder, J T
AU  - Elder JT
LA  - eng
GR  - GM52205/GM/NIGMS NIH HHS/United States
GR  - P30 HG00209-03/HG/NHGRI NIH HHS/United States
GR  - R01 AR4274-01/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Hum Genet
JT  - American journal of human genetics
JID - 0370475
RN  - 0 (Genetic Markers)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
SB  - IM
CIN - Am J Hum Genet. 1999 Mar;64(3):895-6. PMID: 10053024
MH  - Adult
MH  - Age of Onset
MH  - Female
MH  - Genetic Linkage/*genetics
MH  - Genetic Markers
MH  - Germany
MH  - HLA Antigens/*genetics
MH  - HLA-B Antigens/genetics
MH  - HLA-C Antigens/genetics
MH  - Haplotypes/genetics
MH  - Humans
MH  - Lod Score
MH  - Male
MH  - Michigan
MH  - Pedigree
MH  - Phenotype
MH  - Psoriasis/*genetics
PMC - PMC1377223
EDAT- 1998/06/23 02:01
MHDA- 2000/03/21 09:00
PMCR- 1999/01/01
CRDT- 1998/06/23 02:01
PHST- 1998/06/23 02:01 [pubmed]
PHST- 2000/03/21 09:00 [medline]
PHST- 1998/06/23 02:01 [entrez]
PHST- 1999/01/01 00:00 [pmc-release]
AID - S0002-9297(07)60739-3 [pii]
AID - 10.1086/301899 [doi]
PST - ppublish
SO  - Am J Hum Genet. 1998 Jul;63(1):191-9. doi: 10.1086/301899.