PMID- 9634574
OWN - NLM
STAT- MEDLINE
DCOM- 19980702
LR  - 20231014
IS  - 0270-6474 (Print)
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Linking)
VI  - 18
IP  - 13
DP  - 1998 Jul 1
TI  - Small changes in ambient temperature cause large changes in 
      3,4-methylenedioxymethamphetamine (MDMA)-induced serotonin neurotoxicity and core 
      body temperature in the rat.
PG  - 5086-94
AB  - The amphetamine derivative 3,4-methylenedioxymethamphetamine (MDMA) is a drug of 
      abuse and has been shown to be neurotoxic to 5-HT terminals in many species. 
      MDMA-engendered neurotoxicity has been shown to be affected by both ambient 
      temperature and core body temperature. We now report that small (2 degreesC) 
      changes in ambient temperature produce changes in core temperature in 
      MDMA-treated rats, but the same changes in ambient temperature do not affect core 
      temperature of saline-treated animals. Furthermore, increases in core temperature 
      of MDMA-treated animals increase neurotoxicity. Rats were given MDMA (20 or 40 
      mg/kg) or saline and placed in an ambient temperature of 20, 22, 24, 26, 28, or 
      30 degreesC using a novel temperature measurement apparatus that controls ambient 
      temperature +/-0.5 degrees C. Two weeks after MDMA treatment, the rats were 
      killed, and regional 5-HT and 5-hydroxyindole acetic acid levels were analyzed as 
      a measure of neurotoxicity. Rats treated with MDMA at 20 and 22 degrees C showed 
      a hypothermic core temperature response. Treatment with MDMA at 28 and 30 
      degreesC produced a hyperthermic response. At ambient temperatures of 20-24 
      degrees C, neurotoxicity was not observed in the frontal cortex, somatosensory 
      cortex, hippocampus, or striatum. At ambient temperatures of 26-30 degrees C, 
      neurotoxicity was seen and correlated with core temperature in all regions 
      examined. These data indicate that ambient temperature has a significant affect 
      on MDMA neurotoxicity, core temperature, and thermoregulation in rats. This 
      finding has implications on both the temperature dependence of the mechanism of 
      MDMA neurotoxicity and human use because fatal hyperthermia is associated with 
      MDMA use in humans.
FAU - Malberg, J E
AU  - Malberg JE
AD  - University of Chicago, Department of Pharmacological and Physiological Sciences, 
      Chicago, Illinois 60637, USA.
FAU - Seiden, L S
AU  - Seiden LS
LA  - eng
GR  - DA00085/DA/NIDA NIH HHS/United States
GR  - MH-105-62/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Neurotoxins)
RN  - 0 (Serotonin Agents)
RN  - 102-32-9 (3,4-Dihydroxyphenylacetic Acid)
RN  - 333DO1RDJY (Serotonin)
RN  - 451W47IQ8X (Sodium Chloride)
RN  - 54-16-0 (Hydroxyindoleacetic Acid)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
RN  - X77S6GMS36 (Homovanillic Acid)
SB  - IM
MH  - 3,4-Dihydroxyphenylacetic Acid/analysis
MH  - Animals
MH  - Body Temperature/*drug effects
MH  - Body Temperature Regulation/drug effects
MH  - Brain Chemistry/drug effects
MH  - Corpus Striatum/chemistry
MH  - Dopamine/analysis
MH  - Fever/metabolism/mortality
MH  - Frontal Lobe/chemistry
MH  - Hippocampus/chemistry
MH  - Homovanillic Acid/analysis
MH  - Hydroxyindoleacetic Acid/analysis/metabolism
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*toxicity
MH  - Neurotoxins/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin/analysis/metabolism
MH  - Serotonin Agents/*toxicity
MH  - Sodium Chloride/pharmacology
MH  - Somatosensory Cortex/chemistry
MH  - *Temperature
PMC - PMC6792575
EDAT- 1998/06/23 00:00
MHDA- 1998/06/23 00:01
PMCR- 1999/01/01
CRDT- 1998/06/23 00:00
PHST- 1998/06/23 00:00 [pubmed]
PHST- 1998/06/23 00:01 [medline]
PHST- 1998/06/23 00:00 [entrez]
PHST- 1999/01/01 00:00 [pmc-release]
AID - 2116 [pii]
AID - 10.1523/JNEUROSCI.18-13-05086.1998 [doi]
PST - ppublish
SO  - J Neurosci. 1998 Jul 1;18(13):5086-94. doi: 10.1523/JNEUROSCI.18-13-05086.1998.