PMID- 9635129
OWN - NLM
STAT- MEDLINE
DCOM- 19980916
LR  - 20191024
IS  - 1039-9712 (Print)
IS  - 1039-9712 (Linking)
VI  - 45
IP  - 1
DP  - 1998 Jun
TI  - Influence of phenoxyherbicides and their metabolites on the form of oxy- and 
      deoxyhemoglobin of vertebrates.
PG  - 47-59
AB  - The effect of phenoxyherbicides and their metabolites on the structure of oxy- 
      and deoxyhemoglobin was studied by using different doses and times of incubation 
      of hemoglobin with the herbicide. It was ascertained that among the investigated 
      hemoglobins the most sensitive was carp oxyhemoglobin incubated with 2,4-D 
      (2,4-dichlorophenoxyacetic acid) and the least sensitive was human hemoglobin. 
      Comparing the toxicity of 2,4-D, MCPA (2-methyl-4-chlorophenoxyacetic acid), 
      2,4-DCP (2,4-dichlorophenol), 2,4-DMP (2,4-dimethylphenol) it was found that the 
      highest decrease occurred in bovine hemoglobin incubated with 2,4-DMP. The 
      phenoxyherbicides caused stabilization of the structure of T-deoxyhemoglobin in 
      vitro, in that they decreased the oxygen affinity with a simultaneous increase in 
      methemoglobin concentration.
FAU - Bukowska, B
AU  - Bukowska B
AD  - Department of Biophysics Environmental Polution, University of Lodz, Poland.
FAU - Reszka, E
AU  - Reszka E
FAU - Duda, W
AU  - Duda W
LA  - eng
PT  - Journal Article
PL  - England
TA  - Biochem Mol Biol Int
JT  - Biochemistry and molecular biology international
JID - 9306673
RN  - 0 (Chlorophenols)
RN  - 0 (Hemoglobins)
RN  - 0 (Herbicides)
RN  - 0 (Oxyhemoglobins)
RN  - 0 (Xylenes)
RN  - 2577AQ9262 (2,4-Dichlorophenoxyacetic Acid)
RN  - 5OD803C081 (2,4-dimethylphenol)
RN  - 9008-02-0 (deoxyhemoglobin)
RN  - D888C394VO (2-Methyl-4-chlorophenoxyacetic Acid)
RN  - R669TG1950 (2,4-dichlorophenol)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - 2,4-Dichlorophenoxyacetic Acid/metabolism/pharmacology
MH  - 2-Methyl-4-chlorophenoxyacetic Acid/metabolism/pharmacology
MH  - Animals
MH  - Carps
MH  - Cattle
MH  - Chlorophenols/pharmacology
MH  - Hemoglobins/*drug effects/metabolism
MH  - Herbicides/*pharmacology
MH  - Humans
MH  - Oxygen/metabolism
MH  - Oxyhemoglobins/*drug effects/metabolism
MH  - Protein Binding/drug effects
MH  - Xylenes/pharmacology
EDAT- 1998/06/23 00:00
MHDA- 1998/06/23 00:01
CRDT- 1998/06/23 00:00
PHST- 1998/06/23 00:00 [pubmed]
PHST- 1998/06/23 00:01 [medline]
PHST- 1998/06/23 00:00 [entrez]
AID - 10.1080/15216549800202422 [doi]
PST - ppublish
SO  - Biochem Mol Biol Int. 1998 Jun;45(1):47-59. doi: 10.1080/15216549800202422.