PMID- 9637612
OWN - NLM
STAT- MEDLINE
DCOM- 19980625
LR  - 20190813
IS  - 0013-9580 (Print)
IS  - 0013-9580 (Linking)
VI  - 39
IP  - 6
DP  - 1998 Jun
TI  - Nonconvulsive status epilepticus in two patients receiving tiagabine treatment.
PG  - 671-4
AB  - In the course of an open study on the add-on treatment of tiagabine (TGB) in 
      patients with localization-related epilepsy syndromes, 2 of 9 patients developed 
      nonconvulsive status epilepticus (NCSE) with electroclinical features consistent 
      with those of atypical absence seizures. One patient had never had atypical 
      absence seizures before. In both cases, immediate discontinuation of TGB was 
      followed by complete and sustained electroclinical remission; we suggest a 
      possible causative role of TGB. This observation may be consistent with a 
      paradoxical effect of TGB in selected cases. Possible risk factors and a 
      pathophysiological hypothesis are discussed.
FAU - Eckardt, K M
AU  - Eckardt KM
AD  - Department of Clinical Neurophysiology, Georg-August Universitat, Gottingen, 
      Germany.
FAU - Steinhoff, B J
AU  - Steinhoff BJ
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Epilepsia
JT  - Epilepsia
JID - 2983306R
RN  - 0 (Anticonvulsants)
RN  - 0 (Nipecotic Acids)
RN  - Z80I64HMNP (Tiagabine)
SB  - IM
CIN - Epilepsia. 1998 Dec;39(12):1383. PMID: 9860080
MH  - Adult
MH  - Anticonvulsants/*adverse effects/therapeutic use
MH  - Drug Therapy, Combination
MH  - Electroencephalography/*statistics & numerical data
MH  - Epilepsy/drug therapy
MH  - Epilepsy, Absence/*chemically induced/diagnosis
MH  - Female
MH  - Humans
MH  - Nipecotic Acids/*adverse effects/therapeutic use
MH  - Status Epilepticus/*chemically induced/diagnosis
MH  - Tiagabine
EDAT- 1998/06/24 00:00
MHDA- 1998/06/24 00:01
CRDT- 1998/06/24 00:00
PHST- 1998/06/24 00:00 [pubmed]
PHST- 1998/06/24 00:01 [medline]
PHST- 1998/06/24 00:00 [entrez]
AID - 10.1111/j.1528-1157.1998.tb01438.x [doi]
PST - ppublish
SO  - Epilepsia. 1998 Jun;39(6):671-4. doi: 10.1111/j.1528-1157.1998.tb01438.x.